CIRCADIAN AND HOMEOSTATIC SLEEP REGULATION OLDER PEOPLE

老年人的昼夜节律和稳态睡眠调节

• 批准号: 7084874
• 负责人: Charles A Czeisler
• 金额: $ 27.58万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7084874
• 关键词: REM sleep; age difference; aging; circadian rhythms; electroencephalography; homeostasis; human middle age (35-64); human old age (65+); human subject; polysomnography; sleep; sleep deprivation; sleep disorders; wakefulness; young adult human (21-34)

More than a third of adults ages 55 and older report sleeping less than 7h per night on a regular basis, with nearly 15% sleeping <6h per night. The consequences of acute sleep deprivation are well understood, but far less is known about the effects chronic insufficient sleep, particularly in older people. Evidence gathered during the previous grant periods strongly suggests that the sleep quality of older people is extremely vulnerable to a misalignment between the timing of sleep and the phase of the circadian timing system suggests that older people will be less able than young adults to obtain needed recovery sleep following acute sleep loss. There is also compelling evidence that the interaction between the two major sleep regulatory processes, the circadian and the sleep-wake homeostat, changes with age. We propose a study that will assess the effects of chronic sleep restriction in young and older adults, using a study design that will allow us to quantify age-related differences in the impact of circadian and sleep-dependent influences on sleep. The proposed investigation is designed to test the following hypotheses: 1) that notwithstanding the increased homeostatic sleep pressure induced by chronic sleep restriction, sleep will be significantly more disrupted when it is scheduled at adverse circadian phases in older as compared with young adults; 2) that under conditions of chronic sleep restriction, slow-wave activity during sleep will be increased at all circadian phases in both young and older subjects; 3) that the circadian rhythm of REM sleep will be preserved across 4 weeks of chronic sleep restriction in young and older subjects, and that it will be preserved in older subjects at the expense of other sleep stages, including slow-wave sleep; and 4) that unlike the sleep of young subjects, during sleep extension following 4 weeks of chronic sleep restriction, the sleep of older subjects will not show rapid recovery as measured by the duration and intensity of slow-wave sleep, sleep efficiency, and number of awakenings. We propose to test these hypotheses in healthy young and older men and women whose sleep-wake cycle is scheduled to a 28-h day under conditions of chronic sleep restriction (i.e., 22.17 h wake followed by 5.83 h sleep opportunity) on a forced desynchrony protocol across 4 weeks. Polysomnographic sleep recording and quantitative analysis of EEC will be used to describe age-related changes in circadian sleep regulation and to understand the effects of chronic sleep restriction on sleep in older persons. The results of this project will provide important information on the effects of chronic insufficient sleep in older people, a condition which a significant portion of the older population experiences on a regular basis, and an area of investigation in which few laboratory-based investigations have been conducted.

超过三分之一的年龄在55岁及以上的成年人报告定期睡觉不到7h， 每晚近15％的睡眠<6h。急性睡眠剥夺的后果被充分了解， 但是，对于长期睡眠不足的影响，尤其是在老年人中，对这种影响的了解少得多。证据 在上一期期间聚集的强烈表明，老年人的睡眠质量是 非常容易受到睡眠时间和昼夜节律阶段之间的损害 系统表明，老年人比年轻人能够获得所需的康复睡眠的能力 急性睡眠损失。还有令人信服的证据表明，这两个主要的相互作用 睡眠调节过程，昼夜节律和睡眠式体内平衡，随着年龄的增长而变化。我们提出了一个 使用研究设计将评估年轻人和老年人的慢性睡眠限制的影响 这将使我们能够量化与年龄相关的昼夜节律和睡眠依赖性的差异 对睡眠的影响。 拟议的调查旨在检验以下假设：1） 慢性睡眠限制引起的稳态睡眠压力增加，睡眠将大大增加 与年轻人相比，安排在年龄较大的昼夜节律阶段时被破坏； 2）那 在慢性睡眠限制的条件下，所有昼夜节律都会增加睡眠期间的慢波活动 年轻和老年人的阶段； 3）REM睡眠的昼夜节律将被保留 年轻和年龄较大的受试者的长期睡眠限制为4周，并将其保存在较大的人中 受试者以其他睡眠阶段为代价，包括慢波睡眠； 4）与睡眠不同 年轻受试者，在慢性睡眠限制4周后睡眠延长期间，年龄较大的睡眠 通过慢波睡眠的持续时间和强度，受试者不会显示出快速恢复 效率和觉醒的数量。 我们建议在健康的年轻人和年龄较大的男人和女人的睡眠醒来中检验这些假设 在慢性睡眠限制条件下，周期定为28-H天（即22.17 h唤醒，然后是 5.83 h的睡眠机会）在4周的强迫性降解方案上。多个学术睡眠 EEC的记录和定量分析将用于描述与年龄相关的昼夜节律变化 调节并了解慢性睡眠限制对老年人睡眠的影响。 该项目的结果将提供有关慢性睡眠不足的影响的重要信息 老年人，这种情况定期经历了大部分老年人， 以及一个调查领域，很少进行基于实验室的调查。