BRAIN FUNCTION AND AFFECTIVE STYLE IN MIDUS II

MIDUS II 中的大脑功能和情感风格

• 批准号: 6585839
• 负责人: Richard J Davidson
• 金额: $ 5.44万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585839
• 关键词: African American; age difference; aging; behavioral /social science research tag; brain electrical activity; brain imaging /visualization /scanning; caucasian American; clinical research; electroencephalography; emotions; functional magnetic resonance imaging; gender difference; human middle age (35-64); human old age (65+); human subject; longitudinal human study; prefrontal lobe /cortex; psychological adaptation; psychological aspect of aging; psychological stressor; psychophysiology; racial /ethnic difference; startle reaction; stimulus /response

This project builds upon previous work by the PI and others indicating that asymmetrical prefrontal activation derivedfrom brain electrical activity recordings is associated with both psychological and biological indices that reflect affective style. We have found that subjects with greater left prefrontal activation report more dispositional positive affect, have lower levels of basal cortisol, recover more quickly from a laboratory stressor and show higher levels of antibody titer following vaccination with influenza vaccine. During this grant period, we propose to test 400 MIDUS respondents on measuresof brain electrical activity under both baseline conditions and in response to affective stimuli. In addition, using emotion-modulated startle, we will assess startle modulation before, during and after the presentation of positive, negative and neutral pictures to derive indices of affective chronometry, or the time course of emotional responding. Brain electrical activity measures will be analyzed using both conventional spectral power estimates as well as source localization procedures. We predict that subjects with greater left prefrontal activation will show faster recovery following negative challenge. These individuals are also predicted to have lower cortisol (both basal and in response to challenge), lower levels of IL-6 and higher levels of psychological well-being. Analyses will also be conducted to ascertain the impact of cumulative adversity on these biological indices and to determine the extent to which measures of adversity account for variance in brain function and emotion-modulatedstartle over and beyond variance accounted for by contemporary measures of mood and well-being. The data from this project will provide significant clues to understanding the central mechanisms through which cumulative adversity and psychological well-being are instantiated in the brain and affect peripheral biology in ways that may be consequential for health.

该项目基于PI和其他项目的先前工作，表明从脑电活动记录得出的不对称的前额叶活化与反映情感风格的心理和生物学指数有关。我们发现，具有较大左前额叶活化报告的受试者报告更多的倾向积极影响，其基础皮质醇水平较低，从实验室压力源中恢复更快，并在疫苗接种疫苗接种后显示出较高的抗体滴度。在这一赠款期间，我们建议在基线条件下和对情感刺激的响应下测试400名MIDUS受访者对脑电活动的测量。此外，使用情绪调节的惊吓，我们将在提出正面，阴性和中性图片之前，之中和之后评估惊吓调制，以得出情感时间表的指标或情感响应的时间过程。将使用传统的光谱功率估计以及来源定位程序分析大脑电活动度量。我们预测，在负面挑战之后，具有较大左前额叶激活的受试者将显示出更快的恢复速度。这些 还预计个体具有较低的皮质醇（基础和对挑战的反应），IL-6的水平较低，心理健康水平较高。还将进行分析，以确定累积逆境对这些生物学指标的影响，并确定逆境度量的程度，以多大化脑功能的差异和情绪模范的差异，而不是当代的情绪和幸福感所考虑的差异。该项目的数据将为 了解累积逆境和心理健康在大脑中实例化并以可能对健康造成的方式影响外周生物学的中心机制。