DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK

DNA 修复基因多态性与乳腺癌风险

• 批准号: 6648137
• 负责人: TIMOTHY J JORGENSEN
• 金额: $ 5.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-29 至 2004-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6648137
• 关键词: DNA repair; breast neoplasms; cancer risk; clinical research; disease /disorder etiology; gene environment interaction; gene expression; genetic polymorphism; genetic susceptibility; genotype; human subject; ionizing radiation; neoplasm /cancer genetics; radiation carcinogenesis; radiation related neoplasm /cancer

DESCRIPTION (provided by applicant): Investigations of potential gene-environment interactions may improve our understanding of the etiology of breast cancer. The objectives of this proposal are to examine the association between DNA repair gene polymorphisms and breast cancer risk. In this proposal, we hypothesize that DNA repair pathways play an important role in protecting against breast carcinogenesis, and that polymorphisms in DNA repair genes, such as XPD, may influence breast cancer susceptibility in general, and possibly ionizing radiation-induced carcinogenesis, in particular. The applicant proposes to explore this hypothesis by designing and analyzing a nested ease-control study of the association between DNA repair gene polymorphisms and breast cancer incidence in a community-based cohort. Because of a complementary ongoing study, the applicant will also be able to compare the nested case-control results to a cohort analysis available for a subset of the population. The findings from this study will aid in understanding potential genetic susceptibility factors related to breast carcinogenesis, and in identifying women at increased breast cancer risk who may benefit from targeted interventions.

描述（由申请人提供）：对潜在基因环境相互作用的研究可能会改善我们对乳腺癌病因的理解。该提案的目标是检查DNA修复基因多态性与乳腺癌风险之间的关联。在该提案中，我们假设DNA修复途径在预防乳腺癌发生方面起着重要作用，而DNA修复基因（例如XPD）中的多态性可能会影响一般的乳腺癌易感性，并且可能会导致辐射诱导的癌变，尤其是。申请人建议通过设计和分析基于社区的队列中DNA修复基因多态性与乳腺癌发病率之间的关联的嵌套缓解对照研究来探讨这一假设。由于进行了互补的正在进行的研究，申请人还将能够将嵌套的病例对照结果与可用于一部分人群的队列分析进行比较。这项研究的发现将有助于理解与乳腺癌发生有关的潜在遗传敏感性因素，并确定可能受益于有针对性干预措施的乳腺癌风险增加的妇女。