Alcohol Involvement in Asian American Men and Women

亚裔美国男性和女性的饮酒情况

• 批准号: 6509248
• 负责人: TAMARA L WALL
• 金额: $ 28万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509248
• 关键词: Asian Americans; Chinese American; academic achievement; alcoholic beverage consumption; alcoholism /alcohol abuse; attitude; behavioral /social science research tag; blood tests; clinical research; culture; disease /disorder proneness /risk; drug metabolism; expectancy; family genetics; gender difference; gene environment interaction; genetic susceptibility; human subject; interview; peer group; personality; racial /ethnic difference; religion; toxicology; university student; young adult human (21-34)

DESCRIPTION: Asian Americans, as a whole, have lower rates of alcohol use and alcohol use disorders than other ethnic groups in the United States. Studies conducted in Asia, however, indicate that Koreans have a significantly higher lifetime prevalence of alcohol abuse and dependence than Chinese. There are also data to indicate that these two Asian American subgroups vary greatly with respect to patterns, prevalence and consequences of alcohol use. The overall objective of the proposed research project is to determine variables associated with alcohol involvement (alcohol consumption and alcohol-related problems) in 21-25 year old Chinese American and Korean American college students using a risk and protective factor approach. The risk and protective factor dimensions that will be evaluated will focus on factors related to alcohol use and alcohol-related problems in previous studies of Asians and other ethnic groups, including variation in three genes involved in alcohol metabolism (ALDH2, ADH2, and ADH3), other genetically influenced factors (e.g., family history of alcoholism), and psychosocial variables. It is hypothesized that Korean Americans will have fewer protective factors and more risk factors than Chinese Americans. In a subsample of participants, an alcohol and placebo challenge paradigm will be conducted to measure level of response to alcohol in Korean Americans with and without an alcoholic father. It is hypothesized that those with an alcoholic father will demonstrate less intense reactions to alcohol than matched controls without a family history of alcoholism. Additionally, this study proposes to explore, within the sample, potential mediating and moderating relationships between vulnerability factors and alcohol involvement. The study of two Asian American subgroups with significantly different patterns of alcohol consumption and alcoholism offers a unique opportunity to control the influence of some specific genetic factors (variation in the alcohol metabolism genes) while searching for additional influences on alcohol use behavior and how these factors may relate to promote or protect against alcohol problems. Ultimately, a better understanding of the factors associated with alcohol behavior in Asian Americans will contribute important information for understanding the causes of alcohol abuse and dependence and might aid in the development of efficacious and culturally sensitive prevention and intervention programs.

描述：从整体上，亚裔美国人的酒精使用率较低， 与美国其他种族相比，酒精使用障碍。研究 但是，在亚洲进行的，表明韩国人的人数明显更高 终身滥用酒精和依赖性的终身患病率。有 还表明这两个亚裔美国亚组的数据差异很大 涉及酒精使用的模式，患病率和后果。总体 拟议的研究项目的目的是确定相关的变量 随着酒精参与（饮酒和与酒精有关的问题） 21-25岁的华裔美国人和韩裔美国大学的学生使用 风险和保护因素方法。风险和保护因素维度 将评估这将集中在与酒精使用和相关的因素上 在以前对亚洲人和其他种族的研究中，与酒精有关的问题， 包括参与酒精代谢的三个基因的变异（ALDH2，ADH2， 和ADH3），其他遗传影响的因素（例如，家族史 酒精中毒）和社会心理变量。假设韩国人 与中国人相比，美国人的保护因素和风险因素更少 美国人。在参与者的子样本中，酒精和安慰剂挑战 将进行范式以衡量韩国对酒精的反应水平 有和没有酗酒父亲的美国人。假设那些 用酗酒的父亲表现出对酒精的强烈反应 比没有酒精中毒家族史的匹配控制。此外， 这项研究建议在样本中探索潜在的中介和 调节脆弱性因素与酒精参与之间的关系。 对两个具有明显不同模式的亚裔美国亚洲亚组的研究 饮酒和酒精中毒为控制提供了独特的机会 某些特定遗传因素的影响（酒精的变化 代谢基因）在寻找对酒精使用的其他影响时 行为以及这些因素如何与促进或预防酒精有关 问题。最终，更好地理解与 亚裔美国人的酒精行为将为 了解酗酒和依赖的原因，并可能有助于 开发有效和文化敏感的预防和干预 程序。