SIGNAL TRANSDUCTION AND ALZHEIMER'S DISEASE

信号转导与阿尔茨海默病

• 批准号: 6509548
• 负责人: PAUL GREENGARD
• 金额: $ 120.32万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509548
• 关键词: Alzheimer's disease; amyloid proteins; biological signal transduction; molecular pathology

This is the second competing renewal of our Program Project Grant (PPG), entitled, "Signal Transduction and Alzheimer's Disease". This PPG was developed from a program established in the Laboratory of Molecular and Cellular Neuroscience in 1990 for the purpose of investigating the biochemistry, cell biology, molecular biology, and pharmacology of regulation, by protein phosphorylation, of the Alzheimer amyloid precursor protein (APP). A group of experts in various disciplines of biomedical research will carry out these studies using distinct but complementary approaches. The Project, entitled "APP binding proteins, APP phosphorylation and regulation of Cdk5", will examine the interaction between APP and FE65 in neurons, the phosphorylation of APP by Cdk5 in neurons, and the regulation of Cdk5. The Project, entitled "Cellular mechanisms for hormonal regulation of BetaAPP trafficking and ABeta generation", will utilize cell-free systems to advance our understanding of how gonadal hormones and insulin modulate the composition and trafficking of vesicular organelles. The Project, entitled "Signal transduction pathways by which gonadal hormones and insulin regulate intracellular and extracellular levels of ABeta in vitro and in vivo", will identify the receptors and intracellular messengers involved in the signal transduction pathways which modulate the changes in ABeta metabolism caused by gonadal hormones and insulin. These studies will be supported by a Scientific Core that will produce key materials and perform routine, yet critical, tasks that will be required to accomplish the studies described in the other Projects. An Administrative Core will coordinate various aspects of the PPG, integrating day-to-day activities of the investigators and consultants involved in the various projects.

这是我们的计划项目补助金 (PPG) 的第二次竞争更新， 题为“信号转导和阿尔茨海默病”。这个 PPG 是 根据分子和实验室建立的程序开发 1990年的细胞神经科学，目的是研究 生物化学、细胞生物学、分子生物学和调节药理学， 通过阿尔茨海默淀粉样前体蛋白 (APP) 的蛋白质磷酸化。 一群生物医学研究各学科的专家将进行 使用不同但互补的方法进行这些研究。该项目， 题为“APP结合蛋白、APP磷酸化和Cdk5的调节”， 将检查神经元中 APP 和 FE65 之间的相互作用， 神经元中Cdk5对APP的磷酸化以及Cdk5的调节。该项目， 标题为“BetaAPP 贩运激素调节的细胞机制” 和 Abeta 一代”，将利用无细胞系统来推进我们的 了解性腺激素和胰岛素如何调节成分和 囊泡细胞器的贩运。该项目名为“信号 性腺激素和胰岛素调节的转导途径 体外和体内 Aβ 的细胞内和细胞外水平”，将 识别参与信号的受体和细胞内信使 调节 Aβ 代谢变化的转导途径 性腺激素和胰岛素。这些研究将得到科学界的支持 核心将生产关键材料并执行日常工作，但 完成中描述的研究所需的关键任务 其他项目。行政核心将协调各种 PPG 的各个方面，整合研究者的日常活动和 参与各个项目的顾问。