IDENTIFICATION OF PHOSPHORYLATION SITES ON GLUTAMATE RECEPTOR MGLUR5

谷氨酸受体 MGLUR5 磷酸化位点的鉴定

• 批准号: 8361517
• 负责人: PAUL GREENGARD
• 金额: $ 0.13万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361517
• 关键词: Funding; GRM5 gene; Glutamate Receptor; Grant; Mass Spectrum Analysis; Metabotropic Glutamate Receptors; National Center for Research Resources; Phosphorylation Site; Principal Investigator; Research; Research Infrastructure; Resources; Role; Site; Source; United States National Institutes of Health; cost; macromolecule; mutant; novel; receptor function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. we are using hypothesis-driven mass spectrometry to identify novel phosphorylation sites on the metabotropic glutamate receptor, mGluR5. Mutants of the specific sites of phopshorylation will be constructed to obtain information about the roles of these sites on the function of the receptor.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们正在使用假设驱动的质谱法来识别代谢型谷氨酸受体 mGluR5 上的新磷酸化位点。将构建特定磷酸化位点的突变体以获得有关这些位点对受体功能的作用的信息。