SLEEP & FRONTAL LOBE FUNCTION IN REHAB FROM STROKE & TRAUMATIC BRAIN INJURY

睡觉

• 批准号: 6566701
• 负责人: SAMUEL T. KUNA
• 金额: $ 27.93万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6566701
• 关键词: brain injury; clinical research; frontal lobe /cortex; human subject; neuroanatomy; neuropsychological tests; rehabilitation; single photon emission computed tomography; sleep; stroke

Sleep disturbance can be significant after brain damage due to trauma or stroke, but little is known regarding its prevalence and consequences. Patients often complain of symptoms of disturbed sleep and lack of dreaming, and demonstrate inattentiveness, memory difficulties, and easy fatigability, which are commonly associated with sleep disturbance in uninjured populations. In this protocol the sleep of a representative sample of TBI and stroke patients will precisely characterized, and the findings correlated with independent observations of brain function as delineated through formal neuropsychological evaluation. Subjects will be evaluated while attending the post-acute rehabilitation program of the Transitional Learning Community in Galveston. The results will increase our understanding of brain behavior relationships, and provide a scientific basis for intervening beneficially in these populations with better behavioral and pharmacological therapies Such interventions may directly improve quality of life in these patients and enable them to better engage in other rehabilitation efforts. Because stroke and trauma are leading causes of brain damage in the U.S., and cause considerable disability as well as expenditure for health care and rehabilitation, these results could have major public health impact.

由于创伤或中风引起的脑部损伤，睡眠障碍可能很明显，但关于其患病率和后果知之甚少。患者经常抱怨睡眠不安和缺乏梦想，表现出不专心，记忆困难和易于疲劳性的症状，这些症状通常与未受伤的人群中的睡眠障碍有关。 在该协议中，TBI和中风患者的代表性样本的睡眠将精确地表征，并且发现与对大脑功能的独立观察有关，如通过形式的神经心理学评估所描述的。 参加加尔维斯顿过渡学习社区的急性后康复计划时，将对受试者进行评估。 结果将提高我们对大脑行为关系的理解，并为在这些人群中提供更好的行为和药理学疗法的善用提供科学依据，这些干预措施可以直接改善这些患者的生活质量，并使他们能够更好地从事其他康复工作。 由于中风和创伤是美国大脑损害的主要原因，并导致大量残疾以及医疗保健和康复的支出，因此这些结果可能会对公共卫生产生重大影响。