SLEEP & FRONTAL LOBE FUNCTION IN REHAB FROM STROKE & TRAUMATIC BRAIN INJURY

睡觉

• 批准号: 6413640
• 负责人: SAMUEL T. KUNA
• 金额: $ 27.93万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6413640
• 关键词: brain injury; clinical research; frontal lobe /cortex; human subject; neuroanatomy; neuropsychological tests; rehabilitation; single photon emission computed tomography; sleep; stroke

Sleep disturbance can be significant after brain damage due to trauma or stroke, but little is known regarding its prevalence and consequences. Patients often complain of symptoms of disturbed sleep and lack of dreaming, and demonstrate inattentiveness, memory difficulties, and easy fatigability, which are commonly associated with sleep disturbance in uninjured populations. In this protocol the sleep of a representative sample of TBI and stroke patients will precisely characterized, and the findings correlated with independent observations of brain function as delineated through formal neuropsychological evaluation. Subjects will be evaluated while attending the post-acute rehabilitation program of the Transitional Learning Community in Galveston. The results will increase our understanding of brain behavior relationships, and provide a scientific basis for intervening beneficially in these populations with better behavioral and pharmacological therapies Such interventions may directly improve quality of life in these patients and enable them to better engage in other rehabilitation efforts. Because stroke and trauma are leading causes of brain damage in the U.S., and cause considerable disability as well as expenditure for health care and rehabilitation, these results could have major public health impact.

外伤或中风造成脑损伤后，睡眠障碍可能会很严重，但人们对其患病率和后果知之甚少。患者经常抱怨睡眠障碍和缺乏梦的症状，并表现出注意力不集中、记忆困难和容易疲劳，这些通常与未受伤人群的睡眠障碍有关。 在该协议中，将精确描述 TBI 和中风患者代表性样本的睡眠特征，并将结果与​​通过正式神经心理学评估描述的大脑功能的独立观察相关。 受试者将在参加加尔维斯顿过渡学习社区的急性后康复计划时接受评估。 研究结果将增加我们对大脑行为关系的理解，并为通过更好的行为和药物疗法对这些人群进行有益干预提供科学依据。此类干预措施可能会直接改善这些患者的生活质量，并使他们能够更好地参与其他康复工作。 由于中风和创伤是美国脑损伤的主要原因，并导致相当大的残疾以及医疗保健和康复支出，因此这些结果可能会对公共健康产生重大影响。