CORE--NMR

核磁共振

• 批准号: 6660905
• 负责人: CAROL B. POST
• 金额: $ 21.7万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660905
• 关键词: biomedical equipment resource; biomedical facility; neoplasm /cancer; nuclear magnetic resonance spectroscopy; oncology

The goal of the Nuclear Magnetic Resonance (NMR) Shared Resource at the Purdue University Cancer Center is to provide essential NMR services to Cancer Center investigators. These services include providing sample analysis on nine spectrometers and expert assistance to researchers in setting up and interpreting NMR experiments. The funds requested will support this essential resource for Cancer Center members who use NMR in their research. Currently, at least 20 principal investigators with peer reviewed funding make extensive use of the Facility. Specific cancer research areas that utilize the NMR shared resource include: I) Examination of cellular processes involved in human cancer. NMR is used to obtain mechanistic and structural information about proteins and enzymes involved in cell transformation. 2) Studies of the mechanisms of action of anticancer drugs. 3) Development of synthetic routes to known and new anti-cancer agents. NMR is an absolute requirement for the synthetic and drug discovery programs targeted to increase the supply of known anticancer compounds as well as -to devise new compounds. NMR is used to monitor the course of reactions and to determine the structure of these complex synthetic molecules. The NMR Shared Resource provides state of the art NMR equipment and services for cancer researchers at Purdue University. This Facility is critical for the successful completion of many diverse cancer-related research projects and provides a necessary service in efforts to understand and treat cancer.

普渡大学癌症中心共享核磁共振（NMR）共享资源的目标是为癌症中心研究人员提供重要的NMR服务。这些服务包括在建立和解释NMR实验方面为研究人员提供有关九个光谱仪的样本分析和专家帮助。所要求的资金将为使用NMR研究的癌症中心成员提供这一重要资源。目前，至少有20名与同行审查资金的主要调查员广泛使用了该设施。利用NMR共享资源的特定癌症研究领域包括：i）检查涉及人类癌症的细胞过程。 NMR用于获得有关涉及细胞转化的蛋白质和酶的机械和结构信息。 2）研究抗癌药物的作用机理。 3）开发已知和新的抗癌药物的合成路线。 NMR是旨在增加已知抗癌化合物供应的合成和药物发现计划的绝对要求，以及 - 设计新化合物。 NMR用于监测反应的过程，并确定这些复杂的合成分子的结构。 NMR共享资源为普渡大学的癌症研究人员提供了最先进的NMR设备和服务。该设施对于成功完成许多与癌症相关的研究项目至关重要，并为了解和治疗癌症提供了必要的服务。