Software to Aid Assessment of Macular Edema

辅助评估黄斑水肿的软件

• 批准号: 6485068
• 负责人: TIMOTHY J HOLMES
• 金额: $ 10万
• 依托单位: LICKENBROCK TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6485068
• 关键词: computer assisted medical decision making; computer program /software; computer system design /evaluation; diagnosis design /evaluation; edema; eye disorder diagnosis; eye laser surgery; measurement; retina disorder

DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who develop diabetes, 4-15 percent develop macular edema about 8000 per annum register as legally blind. It is simple for the clinician to diagnosis localized (rather than diffuse) edema that has a marked (2 fold or higher) increase in retinal thickness. However, sensitivity to small increases and diffuse edema is not possible. These limits prevent early diagnosis, follow-up monitoring and the accuracy and completeness of laser photocoagulation treatment. A software algorithm is proposed which, in conjunction with scanning laser tomography, will help the physician detect subtle or diffuse increases in thickness by providing and absolute measure of it and by providing a mapping of it over the retinal field of high x, y resolution (about 10 microns). This will help the physicians to see edema early and improve the utility and completeness of laser treatment. Profiles of reflected laser-light intensity, which represent the reflectance of tissue along the z axis (depth into the retina), are collected within a series of optically sectioned images. These profiles are affected by the retinal thickness and have information about the thickness contained within them. They will be processed using a special maximum likelihood parameter estimation algorithm to extract the retinal thickness across the retina, and especially in the region in the around the macula. The objective of this research is to implement prototype software and test this software for feasibility of its principles. The feasibility criterion is based upon showing that the resulting retinal thickness measurements agree with benchmark measurements taken by optical coherence tomography.

描述（由申请人提供）：在5％的北美人中 患糖尿病，4-15％的黄斑水肿每年约8000 在法律上注册。临床医生诊断很简单 具有明显的（2倍或更高）的局部（而不是扩散）水肿 视网膜厚度的增加。但是，对小增加的敏感性， 弥漫性水肿是不可能的。这些限制阻止了早期诊断，随访 监测以及激光光凝的准确性和完整性 治疗。提出了一种软件算法，该算法与扫描结合 激光层析成像将帮助医师检测到细微或弥漫性增加 通过提供和绝对度量的厚度，并提供映射 它在高x，y分辨率的视网膜场上（约10微米）。这会 帮助医生尽早看到水肿并改善效用和完整性 激光治疗。反射激光强度的轮廓， 表示组织沿Z轴的反射率（深度进入视网膜）， 收集在一系列光学切片图像中。这些轮廓是 受视网膜厚度的影响，并具有有关厚度的信息 其中包含在其中。他们将使用特殊的最大值处理 提取视网膜厚度的可能性参数估计算法 遍布视网膜，尤其是在黄斑周围的地区。这 这项研究的目的是实施原型软件并对此进行测试 可行性的软件。可行性标准基于 一旦表明所得的视网膜厚度测量与 光学相干断层扫描进行的基准测量。