Software to Aid Assessment of Macular Edema

辅助评估黄斑水肿的软件

• 批准号: 6485068
• 负责人: TIMOTHY J HOLMES
• 金额: $ 10万
• 依托单位: LICKENBROCK TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6485068
• 关键词: computer assisted medical decision making; computer program /software; computer system design /evaluation; diagnosis design /evaluation; edema; eye disorder diagnosis; eye laser surgery; measurement; retina disorder

DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who develop diabetes, 4-15 percent develop macular edema about 8000 per annum register as legally blind. It is simple for the clinician to diagnosis localized (rather than diffuse) edema that has a marked (2 fold or higher) increase in retinal thickness. However, sensitivity to small increases and diffuse edema is not possible. These limits prevent early diagnosis, follow-up monitoring and the accuracy and completeness of laser photocoagulation treatment. A software algorithm is proposed which, in conjunction with scanning laser tomography, will help the physician detect subtle or diffuse increases in thickness by providing and absolute measure of it and by providing a mapping of it over the retinal field of high x, y resolution (about 10 microns). This will help the physicians to see edema early and improve the utility and completeness of laser treatment. Profiles of reflected laser-light intensity, which represent the reflectance of tissue along the z axis (depth into the retina), are collected within a series of optically sectioned images. These profiles are affected by the retinal thickness and have information about the thickness contained within them. They will be processed using a special maximum likelihood parameter estimation algorithm to extract the retinal thickness across the retina, and especially in the region in the around the macula. The objective of this research is to implement prototype software and test this software for feasibility of its principles. The feasibility criterion is based upon showing that the resulting retinal thickness measurements agree with benchmark measurements taken by optical coherence tomography.

描述（由申请人提供）： 5% 的北美人中 患糖尿病，4-15% 患黄斑水肿，每年约 8000 登记为法定盲人。临床医生诊断简单 具有明显（2倍或更高）的局部（而非弥漫性）水肿 视网膜厚度增加。然而，对小幅增加的敏感性和 弥漫性水肿是不可能的。这些限制妨碍了早期诊断、随访 监测以及激光光凝的准确性和完整性 治疗。提出了一种软件算法，结合扫描 激光断层扫描将帮助医生检测细微或弥漫性的增加 厚度通过提供其绝对测量并通过提供映射 它位于高 x、y 分辨率（约 10 微米）的视网膜视野上。这将 帮助医生及早发现水肿，提高实用性和完整性 的激光治疗。反射激光强度的分布图， 表示组织沿 z 轴（视网膜深度）的反射率， 收集在一系列光学切片图像中。这些配置文件是 受视网膜厚度影响并具有有关厚度的信息 包含在其中。它们将使用特殊的最大处理量进行处理 似然参数估计算法提取视网膜厚度 穿过视网膜，尤其是黄斑周围区域。这 这项研究的目的是实现原型软件并对其进行测试 软件的原理的可行性。可行性标准基于 当显示所得的视网膜厚度测量结果与 通过光学相干断层扫描进行的基准测量。