AUTOMATED 3D TISSUE CHANGE DETECTION/QUANTIFICATION

自动 3D 组织变化检测/量化

• 批准号: 6656984
• 负责人: TIMOTHY J HOLMES
• 金额: $ 45.02万
• 依托单位: LICKENBROCK TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656984
• 关键词: bioimaging /biomedical imaging; biomedical automation; cell component structure /function; computer data analysis; computer program /software; computer system design /evaluation; digital imaging; histology; image processing; immunochemistry; laboratory rat; method development; morphology; morphometry; neurochemistry; three dimensional imaging /topography; tissue /cell culture

DESCRIPTION (Applicant's abstract verbatim): The broad, long-term commercial objective of this project is to produce a prototype software system that leads to a profitable product for tissue characterization by 3D image processing, with a broad popularity among neuroscientists, biologists, industrial pharmacology, food science and other broad applications. The long-term scientific objective is to provide a means for accurately, quickly and economically detecting and monitoring the 3D character of tissue, with a focus on applications in detecting changes in neurological (brain) experimental animal tissue due to specific agents. The innovations of this work are: (1) the novel extension of automated feature extraction and tissue characterization methods to that of 3D image processing, (2) novel extensions and new approaches to such algorithms that will make the algorithm robust against adverse laboratory conditions, (3) developing the first commercial product that comprehensively analyzes the 3D character of biological tissue, (4), a Strategic approach to balancing the amount of labor required by the experimenter to maintain full control over the experiment and to maintain confidence in the results of the experiment versus the level of automation necessary to eliminate tedium, inaccuracies and the prohibitive amount of work that is otherwise necessary in carrying out such comprehensive characterizations, and (5), a novel interactive 3D editor system, which will provide quick, powerful and easy-to-operate 3D point-and-click image editing and 3D morphometric measurement. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（申请人的逐字摘要）：广泛的、长期的商业 该项目的目标是制作一个原型软件系统 成为通过 3D 图像处理进行组织表征的盈利产品， 受到神经科学家、生物学家、工业学家的广泛欢迎 药理学、食品科学等广泛应用。长期来看 科学的目标是提供一种准确、快速、准确的方法 经济地检测和监测组织的 3D 特征，重点是 在检测神经（大脑）实验变化中的应用 动物组织由于特定的制剂。本工作的创新点在于：（1） 自动特征提取和组织表征的新颖扩展 3D 图像处理方法，(2) 新颖的扩展和新方法 此类算法将使算法对不利的情况具有鲁棒性 实验室条件，（3）开发第一个商业产品 全面分析生物组织的3D特征，(4)， 平衡所需劳动力数量的战略方法 实验者保持对实验的完全控制并保持 对实验结果的信心与自动化水平 消除乏味、不准确和令人望而却步的工作量所必需的 进行此类全面的其他必要的 特征，以​​及 (5)，一个新颖的交互式 3D 编辑器系统，它将 提供快速、强大且易于操作的 3D 点击式图像编辑 和 3D 形态测量。 拟议的商业应用： 无法使用