Femtosecond Laser Anterior Lamellar Keratoplasty

飞秒激光前板层角膜移植术

• 批准号: 6551371
• 负责人: Ronald Kurtz
• 金额: $ 10万
• 依托单位: INTRALASE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6551371
• 关键词: computer program /software; computer system design /evaluation; computer system hardware; cornea disorder; eye laser surgery; eye transplantation; keratoplasty; wound healing

DESCRIPTION (provided by applicant): We hypothesize that femtosecond laser technology previously developed for refractive surgical applications can be optimized to perform therapeutic anterior lamellar corneal transplant procedures that are clinically superior to full-thickness and traditional lamellar techniques. Currently, full thickness transplants account for the vast majority of the 45,000 annual corneal transplants performed in the U.S. Most of these procedures could theoretically be replaced with lamellar procedures that include transplantation of either anterior or posterior corneal structures. Replacement of full-thickness corneal transplants with laser lamellar procedures could dramatically reduce complications, lower surgical skill requirements, and speed visual recovery (often delayed with current techniques due to induced astigmatism). In addition, use of a single donor cornea for two patients would significantly improve the shortage that currently exists for donated tissue. To test this hypothesis, we will: Develop hardware and software modifications to the existing femtosecond laser corneal surgery platform : Compare laser-tissue interactions in transparent and translucent tissue to simulate lamellar dissection in normal versus diseased corneas: Model and test self sealing wound architectures for anterior lamellar transplants Model and test self sealing wound architectures for endostromal transplantation through a hinged anterior flap. The goal of the Phase I project will be introduction of software/hardware modifications, as well as the development of surgical techniques for the above procedures that can then undergo clinical testing in a Phase II proposal.

描述（由申请人提供）：我们假设可以优化用于屈光手术应用的飞秒激光技术可以进行优化，以执行治疗性的前层状角膜移植手术程序，这些程序在临床上优于全厚度和传统层状技术。目前，在美国进行的45,000次年度角膜移植中的绝大多数构成了全部厚度移植，从理论上讲，这些手术大多数可以用层状程序代替，包括移植前或后角膜结构。用激光层状手术代替全厚性角膜移植物可以大大减少并发症，降低手术技能要求和速度视觉恢复（通常由于诱导的散光而导致的当前技术延迟）。此外，将单个供体角膜用于两名患者将显着改善目前捐赠组织的短缺。为了检验这一假设，我们将：为现有的飞秒激光角膜手术平台开发硬件和软件修改：比较透明和半透明组织中的激光 - 组织相互作用，以模拟正常的层状扫描，以模拟疾病的角膜和测试自密封型结构，并测试自密封式架构的自封型自封型自封构造自封构造的自封构造工具模型，并测试自封构造的自封构造型号铰链前皮瓣。第一阶段项目的目标是引入软件/硬件修改，以及用于上述过程的手术技术的开发，然后可以在II期提案中进行临床测试。