Research Services

研究服务

• 批准号: 8486474
• 负责人: ANDREW S. GREENE
• 金额: $ 9.53万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8486474
• 关键词: Animals; Area; Bioinformatics; Biomedical Engineering; Biometry; Biotechnology; Chronic; Collaborations; Communication; Complex; Computer Hardware; Computer Systems; Computer software; Computers; Consultations; Contract Services; Contracts; Core Facility; Costs and Benefits; Custom; Data Analyses; Dependence; Documentation; Electronics; Engineering; Equipment; Evaluation; Financial Support; Fostering; Funding; Genetic Services; Genomics; Goals; Grant; Growth; Histology; Hypertension; Ice; Indium; Individual; Laboratories; Life Cycle Stages; Link; Maintenance; Manuals; Mechanics; Microscopy; Modeling; Monitor; Physiological; Physiology; Principal Investigator; Program Research Project Grants; Protocols documentation; Publications; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Services; Source; Speed; Supervision; Support Groups; System; Systems Analysis; Time; United States National Institutes of Health; Vendor; Work; base; computer network; cost; data acquisition; data management; data modeling; design; experience; flexibility; image processing; instrument; instrumentation; meetings; programs; repaired; repository; salt sensitive; skills; tool

The Research Services Core provides basic support for all three Projects and the other two Cores in this Program. The Core facilities in the Department of Physiology at MCW evolved over the last twenty five years from their origin as a Core from a single Program Project grant. As the Department has grown, investigators have found these facilities to be increasingly essential to their research. The current core facilities are supported in part by the Department and other research grants. The continued financial support of these core facilities by the PPG is essential for the work proposed in this Program. Without these Cores, the research proposed in this application could not be conducted. The Research Services Core of this program has expanded in both scope and size during the previous grant period with the addition of new activities in Histology, Microscopy, and Image Processing. Eleven individuals currently staff the Research Sen/ices Core, each with significant experience in a broad range of activities that support the research infrastructure within the Department of Physiology. This staff is divided among one or more support groups, computer, analytical, animal monitoring, microscopy, machine and electronics, and instrument service. Based on the amount of crossover in the activities of these groups we have now found it more productive to unify their efforts into one core under the supervision of Dr. Andrews. Greene. Based on these natural divisions, the Research Services Core serves six main functions within the program project; computer support, analytical and statistical consultation, chronic animal monitoring, microscopy and image processing, custom machine and electronic fabrication, and instrument service. Each of these functions is served by a fully staffed facility which is available at all times to program investigators. Systems management is a key element in sustaining large and complex research efforts such as those supported by the staff of the Research Sen/ices Core. The concept is applied across all areas of the Research Services Core to maximize efficiency and flexibility in design and maintenance of research equipment and facilities used by the principal investigators. The ability to integrate the various component parts of a research protocol into a reproducible and manageable system is a result of combining experienced individuals of complementary skill sets to a given design problem. The objective is to provide a technical infrastructure forthe research programs from the laboratory bench to publication. Providing standard data acquisition systems, analysis programs, data management, and publication tools while extending and maintaining these systems to meet the research goals is the primary activity in this core. The Research Services Core continues to provide direct support to the Program Project Grant with computer hardware, software and networking as well as access to access to skilled machinists and electronic engineers capable of design and repair of specialized research equipmenL The facilities and skills available under one administrative and supervisory unit allow significant cost reductions for maintenance and repair of vital laboratory equipment. The integration of all facets of equipment management speeds repair time by efficient stocking of critical spare parts and effective use of outside specialized maintenance services and contracts. Providing a single point of contact for equipment acquisition and service allows Program Project investigators to benefit from purchase consolidation while enhancing vendor communication and evaluation. This also provides a managed repository for service manuals and user documentation for shared equipment Service histories and maintenance records provide cost benefit input for equipment life cycle management decisions. Computer services and analytical components have historically been an essential component of this Program Project and have always provided services to all of the Projects and Cores. The growth of this Core is a consequence of its place in the center of the integrative activities of this program, since it is literally the facility that provides the key link between the three Projects and the Genomics Core B serving as a vital and the most intensively used resource within the Program. In the previous funding period we have expanded our ability to do theoretical work by developing a close collaboration with the Biotechnology and Biomedical Engineering Center at MCW. This relationship, which fostered the mutual needs of both the Center and the Physiology Department, has been extremely successful. Under this model and in close collaboration the Bioinformatics Research Center within the HMGC, as well as the Division of Biostatistics, PPG investigators are provided with access to large scale, state-of-the-art computing and expertise in sophisticated data analysis and modeling. The machine and electronic core of the PPG provide investigators in the Program Project access to skilled machinists and electronic engineers capable of design and repair of specialized research equipmenL In the previous proposal, these activities were incorporated into the Research Services Core in order to provide all of the research support activities of the Program under one administrative and supervisory unit. The machine and electronic shops are heavily utilized by PPG investigators for both design and fabrication as well as repair of vital equipment in their laboratories. Because of the availability of skilled machinists and engineers within our program, we have been able to reduce our dependence on outside service organizations.

研究服务核心为本计划中的所有三个项目和其他两个核心提供基本支持。 MCW 生理学系的核心设施在过去 25 年中从单一计划项目拨款的核心设施发展而来。随着该部门的发展，研究人员发现这些设施对他们的研究越来越重要。目前的核心设施部分由该部门和其他研究经费支持。 PPG 对这些核心设施的持续财政支持是 对于本计划中提议的工作至关重要。如果没有这些核心，本申请中提出的研究就无法进行。 在上一个资助期间，该计划的研究服务核心在范围和规模上都得到了扩大，增加了组织学、显微镜学和图像处理方面的新活动。研究中心目前有 11 名人员，每个人在支持生理学系研究基础设施的广泛活动中都拥有丰富的经验。该工作人员分为一个或多个支持小组，包括计算机、分析、动物监测、显微镜、机器和电子以及仪器 服务。根据这些小组活动的交叉程度，我们现在发现在安德鲁斯博士的监督下将他们的努力统一为一个核心会更有成效。格林。基于这些自然划分，研究服务核心在计划项目中发挥六大主要职能：计算机支持、分析和统计咨询、慢性动物监测、显微镜和图像处理、定制机器和电子制造以及仪器服务。每项职能均由配备齐全的设施提供，项目调查人员可随时使用该设施。 系统管理是维持大型复杂研究工作（例如由研究服务核心人员支持的研究工作）的关键要素。该概念应用于研究服务核心的所有领域，以最大限度地提高主要研究人员使用的研究设备和设施的设计和维护的效率和灵活性。将研究方案的各个组成部分集成到可重复且可管理的系统中的能力是将具有互补技能的经验丰富的个人与给定的设计问题结合起来的结果。目标是为研究项目从实验室工作台到发表提供技术基础设施。该核心的主要活动是提供标准数据采集系统、分析程序、数据管理和出版工具，同时扩展和维护这些系统以满足研究目标。 研究服务核心继续为计划项目拨款提供直接支持，包括计算机硬件、软件和网络，以及能够接触到能够设计和维修专业研究设备的熟练机械师和电子工程师。 一位行政管理人员提供的设施和技能和监督单位可以显着降低重要实验室设备的维护和维修成本。设备管理各个方面的集成通过有效库存来加快维修时间 关键备件以及有效利用外部专业维护服务和合同。提供设备采购和服务的单点联系使计划项目调查员能够从采购整合中受益，同时加强供应商沟通和评估。这还为共享设备的服务手册和用户文档提供了一个托管存储库。服务历史和维护记录为设备生命周期管理决策提供成本效益输入。 计算机服务和分析组件历来是该计划项目的重要组成部分，并且始终为所有项目和核心提供服务。该核心的发展是其在该计划综合活动中心地位的结果，因为它实际上是提供三个项目和基因组学核心 B 之间关键联系的设施，作为一个重要且最集中的项目程序内使用的资源。 在上一个资助期间，我们通过与 MCW 生物技术和生物医学工程中心开展密切合作，扩大了我们进行理论工作的能力。这种关系非常成功，促进了中心和生理学系的共同需求。在这种模式下，通过与 HMGC 生物信息学研究中心以及生物统计部门的密切合作，PPG 研究人员可以获得大规模、最先进的计算以及复杂数据分析和建模方面的专业知识。 PPG 的机器和电子核心为计划项目的研究人员提供了接触能够设计和维修专业研究设备的熟练机械师和电子工程师的机会。在之前的提案中，这些活动被纳入研究服务核心，以便提供所有该计划的研究支持活动由一个行政和监督单位负责。 PPG 调查人员大量使用机器和电子商店进行设计、制造以及重要部件的维修。 他们实验室的设备。由于我们的计划中拥有熟练的机械师和工程师，我们已经能够减少对外部服务组织的依赖。