Inflammation and Infection in Acquired and Congenital Cardiovascular Disease

获得性和先天性心血管疾病的炎症和感染

• 批准号: 8055920
• 负责人: ANDREW S. GREENE
• 金额: $ 16.35万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8055920
• 关键词: Cardiovascular Abnormalities; Infection; Inflammation

DESCRIPTION (provided by applicant): This application requests funding for a highly interdisciplinary, translational postdoctoral training program focused on inflammation and infection in the development and progression of cardiovascular disease (CVD). Inflammation and infection are receiving increasing attention in the pathophysiology of CVD, yet few groups have assembled that combine expertise in the diverse aspects of inflammation and infection focused on CVD. This innovative program is housed in the Biotechnology and Bioengineering Center (BBC) at the Medical College of Wisconsin because of its central focus on translation of basic science discoveries and technological innovations to disease and clinical medicine. We have formed a unique group of highly qualified academic, industrial, and clinical partners dedicated to outstanding mentoring of postdoctoral trainees in teams. This focused (1 M.D. and 2 Ph.D.) program of 2-3 years duration per trainee will be part of the ongoing fellowship program in the BBC. Our training team members are unified in their belief that contemporary fellowship programs must not only give young scientists an outstanding experience at the bench, but must also provide intensive exposure to a variety of technologies and approaches. Most importantly, young scientists need mentoring that extends beyond the traditional postdoc-mentor relationship. Our diverse colleague network includes not only senior mentors and technical experts (academic consultants), but also junior faculty and peers. This network will provide the most important building blocks for optimal professional development, encompassing an appropriate balance between challenges and support, constructive feedback, overall guidance, providing confidence and emotional support, and building friendships. The training combines an individualized mentoring program via mentoring teams with an individual development plan for each trainee. Mentors include outstanding basic scientists from traditional and non-traditional areas, clinical scientists focused on infection and inflammation in CVD, and representatives from industry to advise our fellows on technology transfer, non-academic career options, and to provide an outside viewpoint on their research. Fellows will be recruited nationally and selected on the basis of academic credentials, research experience, and a commitment to a career in research and training. Training will combine traditional laboratory-based inquiry, short courses, seminars and clinical correlations. Concepts of science management, industrial research and development, technology transfer, patents, and ethics will be explored. Trainees will initially rotate through labs in the BBC to become familiar with capabilities of Genomic and Proteomic technology platforms.

描述（由申请人提供）：本申请要求为高度跨学科的，翻译的博士后培训计划提供资金，该计划的重点是心血管疾病（CVD）的发育和发展中的炎症和感染。在CVD的病理生理学中，炎症和感染正在受到越来越多的关注，但是很少有小组组合在炎症和感染的各个方面，集中于CVD的不同方面。该创新计划位于威斯康星州医学院的生物技术和生物工程中心（BBC）中，因为它主要关注基础科学发现和疾病和临床医学的技术创新。我们组成了一个独特的团队，由高素质的学术，工业和临床合作伙伴组成，致力于在团队中杰出的博士后学员进行杰出的指导。该专注（1 M.D.和2 Ph.D.）计划为每位受训人员2 - 3年，将成为英国广播公司（BBC）正在进行的奖学金计划的一部分。我们的培训团队成员认为，当代奖学金计划不仅必须在替补席上给年轻的科学家提供出色的经验，而且还必须对各种技术和方法进行密集的曝光。最重要的是，年轻的科学家需要指导，这超出了传统的博士后关系。我们多元化的同事网络不仅包括高级导师和技术专家（学术顾问），还包括初级教师和同伴。该网络将为最佳专业发展提供最重要的构建块，涵盖挑战和支持之间的适当平衡，建设性的反馈，整体指导，提供信心和情感支持以及建立友谊。培训通过指导团队与每个学员的个人发展计划结合了个性化的指导计划。导师包括来自传统和非传统领域的杰出基本科学家，专注于CVD感染和炎症的临床科学家，以及来自行业的代表向我们的研究员提供有关技术转移，非学术职业职业选择的建议，并为其研究提供外部观点。研究员将在全国范围内招募，并基于学术证书，研究经验以及对研究和培训职业的承诺。培训将结合传统的基于实验室的询问，短期课程，研讨会和临床相关性。将探讨科学管理，工业研发，技术转移，专利和道德的概念。学员最初将旋转BBC的实验室，以熟悉基因组和蛋白质组学技术平台的功能。