Research Services

研究服务

• 批准号: 8377447
• 负责人: ANDREW S. GREENE
• 金额: $ 10.01万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8377447
• 关键词: Animals; Area; Bioinformatics; Biomedical Engineering; Biometry; Biotechnology; Chronic; Collaborations; Communication; Complex; Computer Hardware; Computer Systems; Computer software; Computers; Consultations; Contract Services; Contracts; Core Facility; Costs and Benefits; Custom; Data Analyses; Dependence; Documentation; Electronics; Engineering; Equipment; Evaluation; Financial Support; Fostering; Funding; Genetic Services; Genomics; Goals; Grant; Growth; Histology; Hypertension; Ice; Indium; Individual; Laboratories; Life Cycle Stages; Link; Maintenance; Manuals; Mechanics; Microscopy; Modeling; Monitor; Physiological; Physiology; Principal Investigator; Program Research Project Grants; Protocols documentation; Publications; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Services; Source; Speed; Supervision; Support Groups; System; Systems Analysis; Time; United States National Institutes of Health; Vendor; Work; base; computer network; cost; data acquisition; data management; data modeling; design; experience; flexibility; image processing; instrument; instrumentation; meetings; programs; repaired; repository; salt sensitive; skills; tool

The Research Services Core provides basic support for all three Projects and the other two Cores in this Program. The Core facilities in the Department of Physiology at MCW evolved over the last twenty five years from their origin as a Core from a single Program Project grant. As the Department has grown, investigators have found these facilities to be increasingly essential to their research. The current core facilities are supported in part by the Department and other research grants. The continued financial support of these core facilities by the PPG is essential for the work proposed in this Program. Without these Cores, the research proposed in this application could not be conducted. The Research Services Core of this program has expanded in both scope and size during the previous grant period with the addition of new activities in Histology, Microscopy, and Image Processing. Eleven individuals currently staff the Research Sen/ices Core, each with significant experience in a broad range of activities that support the research infrastructure within the Department of Physiology. This staff is divided among one or more support groups, computer, analytical, animal monitoring, microscopy, machine and electronics, and instrument service. Based on the amount of crossover in the activities of these groups we have now found it more productive to unify their efforts into one core under the supervision of Dr. Andrews. Greene. Based on these natural divisions, the Research Services Core serves six main functions within the program project; computer support, analytical and statistical consultation, chronic animal monitoring, microscopy and image processing, custom machine and electronic fabrication, and instrument service. Each of these functions is served by a fully staffed facility which is available at all times to program investigators. Systems management is a key element in sustaining large and complex research efforts such as those supported by the staff of the Research Sen/ices Core. The concept is applied across all areas of the Research Services Core to maximize efficiency and flexibility in design and maintenance of research equipment and facilities used by the principal investigators. The ability to integrate the various component parts of a research protocol into a reproducible and manageable system is a result of combining experienced individuals of complementary skill sets to a given design problem. The objective is to provide a technical infrastructure forthe research programs from the laboratory bench to publication. Providing standard data acquisition systems, analysis programs, data management, and publication tools while extending and maintaining these systems to meet the research goals is the primary activity in this core. The Research Services Core continues to provide direct support to the Program Project Grant with computer hardware, software and networking as well as access to access to skilled machinists and electronic engineers capable of design and repair of specialized research equipmenL The facilities and skills available under one administrative and supervisory unit allow significant cost reductions for maintenance and repair of vital laboratory equipment. The integration of all facets of equipment management speeds repair time by efficient stocking of critical spare parts and effective use of outside specialized maintenance services and contracts. Providing a single point of contact for equipment acquisition and service allows Program Project investigators to benefit from purchase consolidation while enhancing vendor communication and evaluation. This also provides a managed repository for service manuals and user documentation for shared equipment Service histories and maintenance records provide cost benefit input for equipment life cycle management decisions. Computer services and analytical components have historically been an essential component of this Program Project and have always provided services to all of the Projects and Cores. The growth of this Core is a consequence of its place in the center of the integrative activities of this program, since it is literally the facility that provides the key link between the three Projects and the Genomics Core B serving as a vital and the most intensively used resource within the Program. In the previous funding period we have expanded our ability to do theoretical work by developing a close collaboration with the Biotechnology and Biomedical Engineering Center at MCW. This relationship, which fostered the mutual needs of both the Center and the Physiology Department, has been extremely successful. Under this model and in close collaboration the Bioinformatics Research Center within the HMGC, as well as the Division of Biostatistics, PPG investigators are provided with access to large scale, state-of-the-art computing and expertise in sophisticated data analysis and modeling. The machine and electronic core of the PPG provide investigators in the Program Project access to skilled machinists and electronic engineers capable of design and repair of specialized research equipmenL In the previous proposal, these activities were incorporated into the Research Services Core in order to provide all of the research support activities of the Program under one administrative and supervisory unit. The machine and electronic shops are heavily utilized by PPG investigators for both design and fabrication as well as repair of vital equipment in their laboratories. Because of the availability of skilled machinists and engineers within our program, we have been able to reduce our dependence on outside service organizations.

研究服务核心为该计划中的所有三个项目以及其他两个核心提供了基本支持。在过去的25年中，MCW生理学系的核心设施从单个计划项目赠款的核心起源而发展。随着部门的发展，调查人员发现这些设施对他们的研究越来越重要。当前的核心设施得到了部门和其他研究补助金的部分支持。 PPG对这些核心设施的持续财政支持对于本计划提出的工作至关重要。没有这些核心，就无法进行本应用中提出的研究。 该计划的研究核心在上一个赠款期间的范围和规模都扩大了，并增加了组织学，显微镜和图像处理方面的新活动。目前有11个人为研究人员核心提供工作，每个人都在支持生理学系内的研究基础设施的广泛活动中拥有丰富的经验。该员工分为一个或多个支持组，计算机，分析，动物监测，显微镜，机器和电子设备以及仪器 服务。根据这些小组的活动的交叉数量，我们现在发现在安德鲁斯博士的监督下，将他们的努力统一为一个核心更加有效。格林。基于这些自然部门，研究服务核心在计划项目中发挥了六个主要功能。计算机支持，分析和统计咨询，慢性动物监测，显微镜和图像处理，定制机器和电子制造以及仪器服务。这些功能中的每一个都由配备人员配备的设施提供服务，该设施始终可用于计划调查人员。 系统管理是维持大型复杂研究工作的关键因素，例如由研究/ICES Core的员工支持的工作。该概念在研究服务核心的所有领域都应用，以最大程度地提高主要研究人员使用的研究设备和设施的效率和灵活性。将研究协议的各个组成部分集成到可重复且易于管理的系统中的能力是将经验丰富的补充技能集合组合到给定设计问题的结果。目的是为从实验室工作台到出版的研究计划提供技术基础设施。在扩展和维护这些系统以实现研究目标的同时，提供标准的数据采集系统，分析程序，数据管理和发布工具是该核心的主要活动。 研究服务核心继续通过计算机硬件，软件和网络为计划项目提供直接支持，并访问能够设计和维修专业研究Equipmenl的熟练机械师和电子工程师。和监督部门允许大幅降低成本，以维护和维修重要的实验室设备。设备管理各个方面的整合通过有效的存放时间来维修时间 关键的备件以及有效使用外部专业维护服务和合同。提供设备采购和服务的单一联系点使计划项目调查人员可以从购买合并中受益，同时增强供应商的沟通和评估。这还为服务手册和用户文档提供了一个托管存储库，用于共享设备服务历史记录和维护记录为设备生命周期管理决策提供了成本收益输入。 从历史上看，计算机服务和分析组件一直是该计划项目的重要组成部分，并且一直为所有项目和核心提供服务。该核心的增长是其在该计划综合活动的中心地位的结果，因为实际上是设施提供了这三个项目与基因组学核心B之间的关键联系程序中使用的资源。 在上一个资金期间，我们通过与MCW的生物技术和生物医学工程中心进行密切合作，扩大了从事理论工作的能力。这种关系增强了中心和生理部门的相互需求，这是非常成功的。在此模型和密切合作的情况下，HMGC内的生物信息学研究中心以及生物统计学的划分，PPG研究人员可以访问大规模，最先进的计算和精致数据分析和建模方面的专业知识。 PPG的机器和电子核心为调查人员提供了计划项目的访问权限，可以在先前的提案中设计和维修专业研究设备的熟练机械师和电子工程师，这些活动已纳入研究服务核心中，以提供所有的活动该计划在一个行政和监督部门下的研究支持活动。 PPG调查人员大量利用了机器和电子商店的设计和制造，并修复了重要 实验室的设备。由于我们计划中熟练的机械师和工程师的可用性，我们能够减少对外部服务组织的依赖。