MECHANISMS OF POST-INJURY ORGAN FAILURE

损伤后器官衰竭的机制

• 批准号: 6605715
• 负责人: ERNEST EUGENE MOORE
• 金额: $ 22.43万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605715
• 关键词: MECHANISMS; POST; INJURY; ORGAN; FAILURE

DESCRIPTION (from the application): This trauma research training program has derived from the research laboratories within the Departments of Surgery, Medicine. Pediatrics, Emergency Medicine and Neurosurgery at the University of Colorado. We have incorporated and benefited from the previous special emphasis review panel (1995) and three formal external reviewers (1999). We envision this fellowship as an opportunity to immerse young academically oriented surgical residents into the basic and clinical investigations concerning the pathophysiology of trauma/burn injuries. The administrative structure of this training program continues to be coordinated through the Principal Investigator/Executive Director/Program Director of the Trauma Research program and a core associate staff. Structurally, each of the trauma research trainees will be based in the surgical core laboratories with access to basic scientists and clinicians on the faculty of the University of Colorado both at Denver Health Medical Center and the University Hospitals. Since our initial funding of two trauma research trainees eight years ago, the Department of Surgery has successfully attracted an NIH Trauma Center grant. The "Center" convenes weekly to critique and share data as well as all equipment. In this fashion, we have constructed the Center as greater than the sum of its parts. The Program Directors are responsible for the recruitment/selection of all trainees and the individual development and integrative direction of each research program. The Program Directors in concert with the multi-disciplinary basic and clinical core associate staff provide both the administrative and scientific link between trainees and their clinical/research endeavors. It is the primary responsibility of the Program Directors to supervise the design and guarantee the implementation of a balanced research training program within the proposed two-year time frame. Each trauma surgical research trainee develops a "research proposal" in concert with the core associate staff prior to initiating the two-year research fellowship. These proposals are reviewed by the Program Directors and presented and critiqued by the entire trauma research center. Thus each trainee has some direction (but typically very little experience) in basic investigation prior to starting the program. During the research training period, each trainee actively participates in the formal weekly research conferences. Each trainee also receives formal didactic instruction in biostatistics, computer application to trauma surgical investigations and biomedical ethics. Trainees have successfully presented their work at meetings of the American Association for the Surgery of Trauma, the Association for Academic Surgery, the Society of University Surgeons, the Surgical Forum, the American Burn Association and FASEB. We have been gratified by the productivity of our Trauma Research trainers. The program is designed to promote the academic and investigative development of surgical residents at the PGY-Ill and PGY-V levels. At both levels the training program is seen as a two year dedicated opportunity (with no clinical responsibilities) to learn the discipline of rigorous basic/clinical investigation. As our young trauma research training program matures, we are gratified that over 90 per cent of our graduates have chosen careers in academic surgery, five have achieved university faculty positions in trauma surgery and two have successfully competed for NIH trauma research funding. Our research-training program is committed to equal opportunity. During the past several years, one-third of our trauma research trainees have been female and one was a minority (currently a NIH-funded member of the trauma faculty at Morehouse University).

描述（来自应用程序）： 该创伤研究培训计划从研究中得出 医学手术部门内的实验室。儿科，紧急情况 科罗拉多大学的医学和神经外科。我们已经合并了 并受益于先前的特别重点评论小组（1995）和三个 正式的外部审稿人（1999）。我们将这一奖学金视为机会 将年轻的学术居民浸入基础和 有关创伤/烧伤损伤的病理生理学的临床研究。 该培训计划的行政结构继续是 通过首席调查员/执行董事/计划协调 创伤研究计划主任和核心助理人员。 从结构上讲，每位创伤研究受训者都将基于 手术核心实验室，与基础科学家和临床医生有关 科罗拉多大学丹佛健康医疗中心的教师 和大学医院。 自八年前我们对两名创伤研究学员的最初资助以来， 外科部成功地吸引了NIH创伤中心补助金。 “中心”每周召集批评和共享数据以及所有 设备。以这种方式，我们建造了比 其部分的总和。该计划董事负责 招聘/选择所有学员和个人发展， 每个研究计划的综合方向。计划主任 与多学科基础和临床核心助理人员音乐会 提供学员及其他们的行政和科学联系 临床/研究努力。这是该计划的主要责任 董事监督设计并保证实施 在拟议的两年时间范围内平衡研究培训计划。 每个创伤外科研究受训者都会在协同中制定“研究建议” 在启动为期两年的研究之前，与核心助理员工一起 奖学金。这些建议由计划董事审查并提出 并受到整个创伤研究中心的批评。因此每个学员有一些 基本调查的方向（但通常很少的经验） 开始程序。在研究培训期间，每个学员 积极参加正式的每周研究会议。每个学员 还可以在生物统计学，计算机上接受正式的教学教学 应用于外科手术研究和生物医学伦理学。学员 在美国协会的会议上成功介绍了他们的工作 为了进行创伤手术，学术手术协会，社会 大学外科医生，外科论坛，美国烧伤协会和 faseb。我们对创伤研究的生产力感到满意 培训师。该计划旨在促进学术和调查 在PGY-ILL和PGY-V水平上发展手术居民。在这两个 培训计划的水平被视为两年的专门机会（有 没有临床责任）学习严格的学科 基本/临床研究。作为我们年轻的创伤研究培训计划 成熟，我们感到满意的是，超过90％的毕业生选择了 学术手术的职业，有五个在大学任职 创伤手术和两次成功竞争了NIH创伤研究 资金。我们的研究培训计划致力于平等机会。 在过去的几年中，我们的创伤研究受训者中有三分之一 是女性，一个是少数（目前是NIH资助的创伤成员 莫尔豪斯大学的教师）。