Acupuncture in Cardiovascular Disease

针灸治疗心血管疾病

• 批准号: 6359787
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 19.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359787
• 关键词: acupuncture /acupressure; afferent nerve; alternative medicine; autonomic nervous system; blood pressure; cardiovascular disorder; cardiovascular disorder therapy; endogenous opioid; heart failure; human subject; human therapy evaluation; neural inhibition; neuroregulation; patient oriented research; positron emission tomography; psychological stressor; stress; striated muscles; sympathetic nervous system; vasoconstriction

DESCRIPTION (provided by applicant): Acupuncture is used to lower blood pressure in patients with hypertension, and to relieve angina in patients with coronary artery disease. While the biological mechanisms of acupuncture analgesia have been studied intensely in animals and humans, the biological mechanisms for modulation of the cardiovascular system in humans remain largely unexplored. Acupuncture at traditional acupoints, and at nonacupoints, decreases the blood pressure response during mental stress in normal humans. This depressor effect cannot be fully explained by a decline in muscle sympathetic nerve activity (MSNA). Further, in humans with heart failure (HF) in whom MSNA is elevated, we have preliminary data that acupuncture significantly decreases the MSNA response during mental stress. The following hypotheses will be tested: 1) acupuncture, performed at traditional acupoints and non-acupoints in normal humans, stimulates skeletal muscle afferent neurons causing a release of endogenous opioids, which oppose sympathetic excitation and vasoconstriction in visceral vascular beds, such as the kidney; 2) in humans with HF in whom MSNA is elevated and renal vasoconstriction is the rule, acupuncture utilizes similar mechanisms as in normal humans to produce I exaggerated inhibition of MSNA and reflex renal vasoconstriction. Positron emission tomography and I microneurography will be utilized to answer the following questions in normal humans and patients with heart failure: 1. Is acupuncture attenuation of BP during mental stress mediated by a decrease in renal vasoconstriction? 2. Is acupuncture sympathoinhibitory? 3. Is acupuncture modulation of the autonomic nervous system during mediated by muscle afferents? 4. Is acupuncture modulation of the autonomic nervous system mediated by activation of endogenous opioids? Understanding the mechanisms of acupuncture modulation of the autonomic nervous system in humans may help clarify its role as a therapeutic modality in cardiovascular diseases, such as heart failure.

描述（申请人提供）：针灸用于降低高血压患者的血压，缓解心绞痛患者的心绞痛。 冠状动脉疾病。针灸的生物学机制 镇痛已经在动物和人类身上进行了深入的研究，生物 人类心血管系统的调节机制在很大程度上仍然存在 未经探索。针灸传统穴位和非穴位， 降低正常人精神压力期间的血压反应。 这种抑制作用不能完全用肌肉下降来解释 交感神经活动（MSNA）。此外，在患有心力衰竭（HF）的人类中 MSNA 升高的患者，我们有初步数据表明针灸 精神压力期间 MSNA 反应显着降低。下列 将测试假设：1）针灸，在传统穴位进行 和正常人的非穴位，刺激骨骼肌传入神经元 引起内源性阿片类药物的释放，对抗交感神经兴奋 以及内脏血管床（例如肾脏）的血管收缩； 2）在 MSNA 升高且肾血管收缩是常见的心衰患者， 针灸利用与正常人类相似的机制来产生 I MSNA 的过度抑制和反射性肾血管收缩。正电子 发射断层扫描和显微神经造影将用于回答 正常人和心力衰竭患者存在以下问题： 1. 精神压力期间针灸对血压的减弱是通过降低血压介导的吗？ 肾血管收缩？ 2. 针灸有交感神经抑制作用吗？ 3. 针灸对自主神经系统的调节作用是由什么介导的？ 肌肉传入？ 4. 针灸对自主神经系统的调节是通过 激活内源性阿片类药物？ 了解针灸调节自主神经的机制 人类系统可能有助于阐明其作为治疗方式的作用 心血管疾病，例如心力衰竭。