High-resolution Dynamic Contrast-enhanced MR Angiography

高分辨率动态对比增强磁共振血管造影

• 批准号: 6547919
• 负责人: WALTER F BLOCK
• 金额: $ 34.77万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6547919
• 关键词: abdomen; angiography; bioimaging /biomedical imaging; biomedical equipment development; blood vessel occlusion; clinical research; computer assisted diagnosis; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; human subject; image enhancement; magnetic resonance imaging; mathematical model; model design /development; phantom model; swine; time resolved data

DESCRIPTION (provided by applicant): This application is a competing renewal for a project titled "High-resolution time- resolved contrast-enhanced MR angiography". The original project introduced the concept that projection acquisitions in MR could be undersampled in high contrast environments. Significant progress produced imaging techniques that deliver four times faster resolution per unit time than Fourier encoding. Several fast scan methods were developed for abdominal, pulmonary, cardiac, peripheral, phase-contrast and T2- weighed imaging. The focus of this competing renewal is on undersampling techniques that take the next step in high resolution 3D MR angiography by dramatically increasing its capabilities for time-resolved imaging. The original project used undersampled projections for the in- plane dimensions and Fourier encoding in the slice dimension. This project acquires 3D projections in all orientations, making the undersampled energy more diffuse and less noticeable. While the speedup factor is comparable with the original project for static imaging, temporal processing of the dataset allows speedup factors that vary with spatial frequency from 40 at the lowest spatial frequencies to 4 at the highest ones. Other features, including isotropic resolution, broad coverage, and insensitivity to contrast arrival time, make this an ideal technique for abdominal contrast-enhanced MR angiography. The aims of the project include 1) shortening the acquisition time by increasing the efficiency of the sampling technique, 2) further developing and evaluating the temporal filtering algorithms for time-resolved imaging, 3) validating the technique against x-ray computed rotational angiography in a swine model of renal artery stenosis, and 4) validating the accuracy of the technique in patients with suspected abdominal vasculature disease. Successful completion of this work will produce an MR exam capable of evaluating the entire abdominal vasculature in a total exam time of less than five minutes.

描述（由申请人提供）：本申请是一个名为“高分辨率时间分辨对比增强磁共振血管造影”项目的竞争性更新。 最初的项目引入了这样的概念：MR 中的投影采集可能会在高对比度环境中欠采样。成像技术取得了重大进展，每单位时间的分辨率比傅里叶编码快四倍。开发了几种用于腹部、肺部、心脏、外周、相差和 T2 加权成像的快速扫描方法。 这一竞争性更新的重点是欠采样技术，该技术通过显着提高其时间分辨成像能力，在高分辨率 3D MR 血管造影方面迈出了下一步。原始项目对平面内维度使用欠采样投影，并在切片维度中使用傅立叶编码。该项目获取所有方向的 3D 投影，使欠采样能量更加分散且不那么明显。虽然加速因子与静态成像的原始项目相当，但数据集的时间处理允许加速因子随空间频率变化，从最低空间频率的 40 到最高空间频率的 4。其他功能，包括各向同性分辨率、广泛的覆盖范围和对造影剂到达时间不敏感，使其成为腹部造影增强 MR 血管造影的理想技术。该项目的目标包括 1) 通过提高采样技术的效率来缩短采集时间，2) 进一步开发和评估用于时间分辨成像的时间滤波算法，3) 在 X 射线计算机旋转血管造影中验证该技术猪肾动脉狭窄模型，4) 验证该技术在疑似腹部血管疾病患者中的准确性。成功完成这项工作将产生能够在不到五分钟的总检查时间内评估整个腹部脉管系统的 MR 检查。

项目成果

Combined time-resolved and high-spatial-resolution 3D MRA using an extended adaptive acquisition.

使用扩展自适应采集将时间分辨和高空间分辨率 3D MRA 相结合。

• DOI: 10.1002/jmri.10071
• 发表时间: 2002
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Mazaheri,Yousef;Carroll,TimothyJ;Du,Jiang;Block,WalterF;Fain,SeanB;Hany,ThomasF;Aagaard,BeverlyDL;Strother,CharlesM;Mistretta,CharlesA;Grist,ThomasM
• 通讯作者: Grist,ThomasM