Realtime 3D MRI Technologies for Therapy and Diagnosis

用于治疗和诊断的实时 3D MRI 技术

• 批准号: 7104582
• 负责人: WALTER F BLOCK
• 金额: $ 25.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7104582
• 关键词: X ray; angiography; birth; chemotherapy; clinical research; computers; diagnosis; fasting; liver; neoplasm /cancer

DESCRIPTION (provided by applicant): The quality of life and survival for cancer patients are considerably threatened by liver metastases. While surgical resection is often not possible and systemic chemotherapy is largely ineffective, promising interventional therapeutic techniques are available. The focus of this project is to demonstrate the effectiveness of real-time time-resolved 3D MR guidance for one such technique: transcatheter arterial chemoembolization (TACE). Successful completion of the project will not only allow immediate improvement of TACE procedure, but should prove to be a capable foundation for other drug delivery techniques where fusing information of local vasculature and anatomy is beneficial. Current guidance for TACE from X-ray Digital Subtraction Angiography( DSA) provides thick 2D projection images with little information on tumor location while increasing the already high dose of ionizing radiation received by liver tumor patients. While MR imaging has provided 3D capabilities for some time, further improvements in acquisition speed, reconstruction processing, and visualization are necessary to apply real-time 3D MRI to new problems. Challenges are derived from the extraordinary increase in data created by 4D imaging. But opportunities are derived from the rapid development of parallel imaging in MRI, new paradigms for using MR's multiple contrast mechanisms, and the continued dramatic improvement in computing power. This project aims to develop 4D MRI, three spatial dimensions plus time, to better visualize the structure and significance of the vasculature adjacent to tumors, and integrate it with the other interventional imaging methods necessary for TACE. Specifically, the first two specific aims of this project concentrate on reconstruction and visualization: 1) Improve MR imaging speed and coverage using faster, more efficient non-Cartesian techniques and integrating these into a real-time reconstruction platform and 2) visualizing of 4D data using a computer cluster. The third aim integrates these developments with other capabilities necessary for MR guidance including catheter visualization and 3D T2-weighted imaging for lesion conspicuity. The last aim verifies these capabilities using the same methods used to validate clinical TACE. Successful completion will provide the necessary information to support a later human trial and a platform for guiding TACE as well as drug delivery in general. Outcomes for the first two aims will also shorten acquisition time, improve image quality, and simplify interpretation of time-resolved diagnostic MR angiography.

描述（由申请人提供）：癌症患者的生活质量和生存质量受到肝转移的威胁。尽管通常无法进行手术切除，并且全身化疗在很大程度上是无效的，但有希望的介入治疗技术。该项目的重点是证明实时时间分辨的3D MR指南的有效性：经导管动脉化学栓塞（TACE）。该项目的成功完成不仅将允许立即改善TACE程序，而且应该被证明是其他药物输送技术的有能力的基础，在这些技术中，将局部脉管系统和解剖结构的信息融合是有益的。当前对X射线数字减法血管造影（DSA）TACE的指导提供了厚的2D投影图像，而肿瘤位置的信息很少，同时增加了已经很高剂量的电离辐射剂。虽然MR成像提供了一段时间提供3D功能，但需要进一步改善采集速度，重建处理和可视化才能将实时3D MRI应用于新问题。挑战来自4D成像创建的数据的非凡增加。但是，机会源于MRI中并行成像的快速发展，使用MR的多种对比机制的新范式以及计算能力的持续急剧改善。该项目旨在开发4D MRI，三个空间维度加上时间，以更好地可视化与肿瘤相邻的脉管系统的结构和意义，并将其与TACE所需的其他介入成像方法相结合。具体而言，该项目的前两个特定目的集中在重建和可视化上：1）使用更快，更有效的非卡提斯技术提高MR成像速度和覆盖速度，并将其集成到实时重建平台中，以及2）使用计算机群集可视化4D数据。第三个目标将这些发展与MR指南所需的其他功能相结合，包括导管可视化和3D T2加权成像，以进行病变。最后一个目标使用用于验证临床TACE的相同方法来验证这些功能。成功完成将提供必要的信息，以支持后来的人类试验，并提供指导TACE以及一般药物的平台。前两个目标的结果也将缩短获取时间，提高图像质量，并简化对时间分辨诊断MR血管造影的解释。