Genetic And Environmental Factors In Adult Nonmalignant

成人非恶性的遗传和环境因素

• 批准号: 6535002
• 负责人: STEPHANIE JOAN LONDON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6535002
• 关键词: Chinese; antioxidants; asthma; blood tests; chronic bronchitis; clinical research; diet; dietary constituent; dietary supplements; disease /disorder proneness /risk; gene environment interaction; genetic polymorphism; genetic susceptibility; health surveys; human subject; interview; longitudinal human study; lung disorder; passive smoking; questionnaires; respiratory disorder epidemiology; tobacco abuse; urinalysis

Aims: The aim of this project is to examine the role of environmental, dietary and genetic factors in determining the risk of developing asthma and chronic bronchitis in a cohort of over 50,000 older adults of Chinese ethnicity in Singapore. There is clear evidence of a role for genetic factors in asthma, evidence for chronic bronchitis is mounting. However, there are few prospective data to address these issues. The possible protective role of diet, including intake of micronutrient antioxidants, as well as the role of macronutrient and caloric balance is of increasing interest but prospective data are essential to examine these associations in an unbiased manner. Procedures and techniques: To do this, we have expanded the scope of a cohort established to examine the relation between diet and cancer. This NCI-funded study includes detailed dietary information using a questionnaire developed for and validated in this population. Follow-up, funded by NCI, includes a telephone interview followed by collection of blood and urine. To expand the capability of the cohort to the study of chronic bronchitis and asthma, we added questions on these entities to the follow-up. In addition, smoking and environmental tobacco smoke data has been expanded. Over the next 4 years as follow-up of the cohort is completed, we will be able to conduct epidemiologic analyses to examine risk factors and modifiers for nonmalignant respiratory disease in adults. Genetic polymorphisms for these conditions can be examined in nested case-control samples. This population is of particular interest because the Chinese women in Singapore and elsewhere have been reported to have high rates of chronic bronchitis in the face of low levels of smoking. The reason for this pattern is unknown. This Chinese population also has high intake of micronutrients that may modify the risk of lung disease. Accomplishments: The follow-up of the cohort is underway. The follow-up questionnaire with our new nonmalignant respiratory disease outcome questions has been administered to 18,000 subjects. We have received this partial dataset and have begun preliminary analyses. We anticipate being able to write manuscripts in FY2002 when the number of subjects enrolled will provide adequate study power for analysis of risk factors for new onset symptoms.

目的：该项目的目的是研究环境，饮食和遗传因素在确定新加坡50,000多名中国族裔老年人中患哮喘和慢性支气管炎的风险中的作用。有明确的证据表明遗传因素在哮喘中的作用，慢性支气管炎的证据正在加剧。但是，几乎没有可解决这些问题的潜在数据。饮食的可能保护作用，包括摄入微量营养素抗氧化剂，以及大量营养素和热量平衡的作用是越来越多的兴趣，但是前瞻性数据对于以公正的方式检查这些关联至关重要。程序和技术：为此，我们扩大了建立的队列范围，以检查饮食与癌症之间的关系。这项由NCI资助的研究包括使用为该人群开发和验证的问卷调查的详细饮食信息。由NCI资助的后续措施包括电话采访，然后收集血液和尿液。为了将队列的能力扩展到研究慢性支气管炎和哮喘的研究，我们在后续行动中添加了有关这些实体的问题。此外，吸烟和环境烟草烟数据已扩大。在接下来的4年中，随着队列的随访完成，我们将能够进行流行病学分析，以检查成人非恶性呼吸道疾病的危险因素和修饰符。这些条件的遗传多态性可以在嵌套的病例对照样本中检查。该人群特别令人感兴趣，因为据报道，新加坡和其他地方的中国妇女面对吸烟水平低的慢性支气管炎率很高。这种模式的原因未知。这种中国人群的微量营养素也很高，可以改变肺部疾病的风险。成就：队列的随访正在进行中。我们的新非恶性呼吸疾病结局问题的后续问卷已针对18,000名受试者进行了管理。我们已经收到了该部分数据集并开始进行初步分析。我们预计，当招募的受试者人数将提供足够的研究能力，以分析新发作症状的风险因素时，能够在2002财年编写手稿。