Genetic and environmental factors in cancer

癌症的遗传和环境因素

• 批准号: 7327212
• 负责人: STEPHANIE JOAN LONDON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7327212
• 关键词: Genetic; environmental; factors; cancer

This project includes two lung cancer studies and my work with the NIEHS sister study. The first is a case-control study of genetic susceptibility to lung cancer in African-Americans and Caucasians in Los Angeles. I conducted this study while a faculty member at the University of Southern California. I have examined a large number of genetic polymorphisms relevant to lung cancer in this study. I am collaborating with my former student from USC on an analysis of isothiocyanates, GSTM1 polymorphisms and lung cancer risk, a follow-up of my Shanghai study finding. A second study is a pooling project where I have contributed my lung cancer data to a collaborative study to pool across a number of lung cancer studies to provide sufficient power for studying gene-environment interactions. I serve on the advisory committee for this pooling project. The third lung cancer study is a collaboration with a prospective cohort study of men in Shanghai, China. This study is based at the University of Southern California. I have been investigating genetic, dietary and environmental factors for lung cancer in this cohort for the past several years. I have done this work using what is called a nested-case control study design. This uses samples from all diagnosed cases of lung cancer and a matched set of controls from the cohort who have not developed cancer. The major strengths of this study are the prospective design and the unique exposures of the Shanghai Cohort. I have published prospective studies of a gene-diet interaction (isothiocyanates and GSTM1 polymorphism) and IGF-1 in relation to lung cancer in the Shanghai Cohort. The genetic studies have used DNA extracted from archival serum samples which presents logistic challenges. This extramurally funded study has recently been renewed for an additional five years of follow-up by NCI. I wrote the portions of the grant dealing with lung cancer. The lung cancer work that was funded includes studying interactions between selenium levels in serum and polymorphisms in selenoproteins and another study of biomarkers of aflatoxin intake in interaction with polymorphisms in DNA repair genes. This study is extramurally funded. In other breast cancer research, I am also a collaborator on the Sister Study having been involved in the initial concept.

该项目包括两项肺癌研究以及我在NIEHS姊妹研究中的工作。第一个是对洛杉矶非裔美国人和高加索人遗传易感性的病例对照研究。我在南加州大学的一名教职员工时进行了这项研究。在这项研究中，我检查了与肺癌相关的大量遗传多态性。我正在与USC的前学生合作，分析异硫氰酸酯，GSTM1多态性和肺癌风险，这是我上海研究发现的后续。 第二项研究是一个合并项目，我将我的肺癌数据贡献给了一项协作研究，以遍及许多肺癌研究，以提供足够的能力来研究基因环境相互作用。我在这个合并项目的咨询委员会任职。 第三项肺癌研究是与中国上海男性的前瞻性队列研究合作。这项研究位于南加州大学。在过去的几年中，我一直在研究该队列中肺癌的遗传，饮食和环境因素。我使用所谓的嵌套控制研究设计进行了这项工作。这使用了所有已诊断出的肺癌病例的样本以及尚未患上癌症的队列的一组对照组。这项研究的主要优势是上海队列的前瞻性设计和独特的暴露。我已经发表了关于基因 - 丁字相互作用（异硫氰酸酯和GSTM1多态性）和IGF-1的前瞻性研究，该研究与上海同胞中有关肺癌的研究。遗传研究使用了从档案血清样品中提取的DNA，这些DNA提出了逻辑挑战。 NCI最近对这项外部资助研究进行了续签五年的随访。我写了有关肺癌的赠款的部分。资助的肺癌工作包括研究血清中硒水平与硒蛋白中多态性的相互作用，以及对黄曲霉毒素摄入的生物标志物在DNA修复基因中与多态性相互作用时的生物标志物的另一项研究。这项研究是在外部资助的。 在其他乳腺癌研究中，我还是姐妹研究的合作者，参与了最初的概念。