Selenium Levels and Cognitive Decline in Elderly Chinese

中国老年人的硒水平和认知能力下降

• 批准号: 7230471
• 负责人: SUJUAN GAO
• 金额: $ 30.42万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7230471
• 关键词: Affect; Alleles; Alzheimer' s Disease; Antioxidants; Apolipoprotein E; Area; Asthma; Biological; Biological Aging; Biological Process; Blood specimen; Cardiovascular Diseases; Cereals; Chinese People; Communities; Dementia; Disease; Eating; Economics; Elderly; Enzymes; Epidemiologic Studies; Food; Free Radicals; Genotype; Health; Health Status; Human; Immune; Impaired cognition; Individual; Inflammation Process; Interview; Life; Link; Longitudinal Studies; Maintenance; Malignant Neoplasms; Measurement; Measures; Medical History; Neonatal; Neuropsychological Tests; Numbers; Paper; Participant; Population; Reaction; Registries; Reporting; Reproduction; Research Personnel; Research Project Grants; Risk; Risk Factors; Rural; Rural Population; Sampling; Scientist; Screening procedure; Selenium; Soil; Structure of nail of toe; Testing; Trace Elements; Water; cognitive function; demographics; dietary supplements; environmental agent; enzyme activity; glutathione peroxidase; indexing; instrument; programs

DESCRIPTION (provided by applicant): The proposed research project is a longitudinal epidemiologic study aimed at confirming or refuting the hypothesis that long-term low selenium exposure is associated with greater cognitive decline. Selenium is a trace element associated with the activity of the antioxidant enzyme glutathione peroxidase. It is considered to be a defensive agent against free radicals through the maintenance of better enzyme activity. Associations between low selenium and increased risk in various disease indices (cancer, cardiovascular disease, reproduction and neonatal health, and asthma) have been reported. The limited studies on selenium and cognitive function or Alzheimer's disease, however, have not reached unequivocal conclusions. Studying the relationship between long-term selenium exposure and cognitive decline in the US population is difficult because the population is mobile and consumes foods that were produced and prepared in different areas of the world. Selenium exposure in the US population is also highly confounded by supplements that are related to the socio-economic and health status of the individuals. The rural Chinese population, in contrast to the US population, is unusually stable with most living in the same village throughout their entire life and consuming food that is locally grown. It is also rare for these villagers to take dietary supplements. Most importantly, selenium as an environmental agent has been studied extensively by Chinese scientists. We propose to conduct a longitudinal study on approximately 2000 rural Chinese age 65 and over with half of them from low selenium areas and the other half from normal selenium areas. The stability of this rural population allows for lifetime exposure estimates to environmental selenium. We hope to test the hypothesis that low selenium exposure is associated with greater cognitive decline. We will also determine the APOE genotype distribution in this population and test the hypothesis that possessing an APOE e4 increases the risk for cognitive decline. We will investigate whether the strength of the association between low selenium and cognitive decline is affected by APOE genotype. In addition we will try to identify other risk factors associated with cognitive decline in this population.

描述（由申请人提供）：拟议的研究项目是一项纵向流行病学研究，旨在确认或驳斥长期硒暴露与更大的认知能力下降有关的假设。硒是与抗氧化剂谷胱甘肽过氧化物酶的活性相关的痕量元素。通过维持更好的酶活性，它被认为是防御性自由基的防御剂。据报道，低硒和风险增加的各种疾病指数（癌症，心血管疾病，繁殖和新生儿健康和哮喘）之间的关联。但是，关于硒和认知功能或阿尔茨海默氏病的有限研究尚未得出明确的结论。由于人口是流动的，并且消耗在世界各地生产和制备的食物，因此很难研究美国人口长期硒与认知能力下降之间的关系。美国人口中的硒暴露也与与个人的社会经济和健康状况有关的补充剂高度混淆。与美国人口相比，农村中国人口非常稳定，大多数人一生都生活在同一个村庄，并且食用当地种植的食物。这些村民也很少服用饮食补充剂。最重要的是，硒作为环境特工已经由中国科学家进行了广泛的研究。我们建议对大约2000个65岁及65岁农村的纵向研究，其中一半来自低硒地区，另一半来自正常的硒地区。该农村人口的稳定性允许对环境硒的终生暴露估计。我们希望检验以下假设：低硒暴露与更大的认知下降有关。我们还将确定该人群中的APOE基因型分布，并检验具有APOE E4的假设会增加认知能力下降的风险。我们将研究低硒和认知下降之间的关联的强度是否受APOE基因型的影响。此外，我们将尝试确定与该人群认知能力下降相关的其他风险因素。