CORE--EPIDEMIOLOGY

核心--流行病学

• 批准号: 6588134
• 负责人: ELLEN B. GOLD
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-22 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588134
• 关键词: agriculture worker; biomarker; biomedical facility; disease /disorder proneness /risk; dust; environmental exposure; environmental toxicology; epidemiology; gene environment interaction; histology; human data; nervous system disorder; occupational disease /disorder; occupational health /safety; pesticides; postmortem; reproductive system disorder; respiratory toxin; urinalysis

Description (provided by applicant): The overall goal of this research is to characterize the exposures and associated determinants of disease among populations exposed to toxic chemicals in the agricultural workplace to this end, this Core encourages and facilitates research to assess the contribution of potentially toxic agrochemical exposures to symptoms or disease in the exposed populations. The research involves the interaction of disciplines involved in the epidemiologic study of disease occurrence, exposure assessment and characterization of toxic exposures, effects, and likely routes of transmission. Each project may involve some or all of these components. The interaction of epidemiology with exposure assessment (industrial hygiene) represents a traditional model in occupational/environmental epidemiologic investigations. The integration of laboratory analyses with epidemiologic data, sometimes referred to as molecular or biochemical epidemiology, is also an important approach to studying, the determinants and mechanisms of disease and adverse health effects of exposures. In these studies, the laboratory investigators work with epidemiologists to measure both markers of exposure in biologic specimens, and markers of effect. For example, measurement of organophosphate metabolites in urine is a marker of exposure, while assessment of urinary endocrine markers of reproductive function is a marker of effect. The investigation of dust exposure and pulmonary pathology in lungs from deceased Hispanic males obtained from coroners' cases includes both biomarkers of exposure (lung dust content and composition) and effect (pathologic changes in the lung).

描述（由申请人提供）：这项研究的总体目标是 表征疾病的暴露和相关决定因素 在农业工作场所暴露于有毒化学物质的种群 最后，该核心鼓励和促进研究以评估贡献 潜在的有毒农业化学暴露于症状或疾病 裸露的人群。该研究涉及学科的相互作用 参与疾病发生的流行病学研究，暴露评估 并表征有毒的暴露，效果和可能的路线 传播。每个项目可能涉及一些或全部这些组件。这 流行病学与暴露评估的相互作用（工业卫生） 代表职业/环境流行病学的传统模型 调查。实验室分析与流行病学的整合 数据有时也称为分子或生化流行病学，也是 研究的重要方法，疾病的决定因素和机制 和暴露的不利健康影响。在这些研究中，实验室 研究人员与流行病学家合作，测量两种暴露标记 生物标本和效果标记。例如，测量 尿液中的有机磷酸代谢物是暴露的标志，而评估 生殖功能的泌尿内分泌标记物是效应的标记。 从 从死因裁判官案中获得的已故西班牙裔男性包括两个生物标志物 暴露（肺灰尘含量和成分）和作用（病理变化 在肺中）。