Epidemiology and Biostatistics

流行病学和生物统计学

• 批准号: 8367350
• 负责人: ELLEN B. GOLD
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-12 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8367350
• 关键词: Animals; Basic Science; Biometry; Biostatistics Core; Carpal Tunnel Syndrome; Clinical; Clinical Trials; Collaborations; Communities; Confounding Factors (Epidemiology); Consultations; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Decision Making; Degenerative polyarthritis; Diagnosis; Discipline; Disease; Drug Formulations; Ensure; Epidemiologic Studies; Epidemiologist; Epidemiology; Exclusion Criteria; Experimental Designs; Goals; Health Sciences; Individual; Instruction; Interdisciplinary Study; Intervention; Knee Osteoarthritis; Kyphosis deformity of spine; Longevity; Measures; Methods; Musculoskeletal; Musculoskeletal Diseases; Nature; Participant; Physical activity; Pilot Projects; Play; Prevention; Quality Control; Randomized Clinical Trials; Research; Research Design; Research Personnel; Resolution; Risk Factors; Role; Secure; Selection Criteria; Services; Sex Characteristics; Shapes; System; Systems Analysis; Techniques; Translational Research; Translations; Ultrasonography; Work; Writing; bone; bone mass; comparison group; data management; design; experience; human population study; inclusion criteria; instrument; interdisciplinary collaboration; population based; relational database; success; tool

The purpose of the Epidemiology and Biostatistics Core (EBC) is to provide all projects in this SCOR with guidance and collaboration regarding study design and data analyses. The EBC will play a central role in integrating the basic science of the animal study, the human population study (epidemiology), and the biomedical/clinical and experimental/clinical investigations. The EBC has two overarching goals: 1) facilitating the goals of the projects and enhancing integration of inter-disciplinary research and translation of basic health science and epidemiologic and clinical investigation into practical tools for the diagnosis, prevention and treatment of musculoskeletal disease in clinical and community-based populations; and 2) providing guidance and collaboration for all four projects and pilot projects regarding study design, data management and data analyses. The EBC will provide advice and collaboration in hypothesis formulation, experimental and study design, selection of comparison groups, inclusion and exclusion criteria, random assignment of participants in the two clinical trials, standard data collection instruments and methods (including quality control measures for data collection), selection of and criteria for potential confounding variables, appropriate statistical analytic techniques and interpretation of results of data analyses. The investigators in the EBC will work with the project investigators to develop, implement, analyze and write up the results of the projects of this SCOR. The EBC has four primary aims: 1) to provide high quality consultation and collaboration in the design of the studies of this SCOR, working closely with project leaders and investigators to design research questions and data collection tools that will facilitate appropriate and accurate analyses of data and appropriate selection of study groups to provide efficient designs; 2) to provide assistance in developing and implementing data management systems to facilitate effective, efficient and secure management and analyses of data; 3) to provide appropriate and timely quantitative statistical analyses for all projects; and 4) to provide appropriate, insightful interpretation of the results of statistical analyses provided to the projects. The Co-Directors of the EBC have decades of experience and well- established expertise in study design, data collection, and statistical analyses for both observational and experimental (specifically, clinical trial) studies and are well-equipped to make decisions jointly for this Core. They also have extensive experience in collaborating with investigators from many different disciplines and are dedicated to inter-disciplinary collaboration and providing well-informed advice.

流行病学和生物统计学核心（EBC）的目的是为该SCOR中的所有项目提供 有关研究设计和数据分析的指导与协作。 EBC将在 整合动物研究的基础科学，人群研究（流行病学）和 生物医学/临床和实验/临床研究。 EBC有两个总体目标：1） 促进项目的目标，并增强跨学科研究的整合和翻译 基本的健康科学和流行病学和临床研究，用于诊断的实用工具， 预防和治疗临床和社区人群中肌肉骨骼疾病；和2） 为研究设计，数据提供所有四个项目和试点项目的指导和协作 管理和数据分析。 EBC将提供假设配方中的建议和协作， 实验和研究设计，比较组的选择，包含和排除标准，随机 在两个临床试验，标准数据收集工具和方法中分配参与者 （包括数据收集的质量控制措施），潜在混淆的选择和标准 变量，适当的统计分析技术和数据分析结果的解释。这 EBC的调查人员将与项目调查人员合作开发，实施，分析和写出 该SCOR项目的结果。 EBC有四个主要目标：1）提供高质量 与项目负责人紧密合作的研究设计研究和协作 和研究人员设计研究问题和数据收集工具，以促进适当的和 准确分析数据和适当选择研究组以提供有效的设计； 2）到 在开发和实施数据管理系统方面提供帮助，以促进有效，高效 并确保对数据的管理和分析； 3）提供适当及时的定量统计 分析所有项目； 4）为统计结果提供适当的，有见识的解释 提供给项目的分析。 EBC的联合导演具有数十年的经验和良好的经验 在研究设计，数据收集和统计分析方面既建立了专业知识 实验性（特别是临床试验）研究，并且能够为该核心共同做出决策。 他们在与来自许多不同学科的调查人员合作方面也有丰富的经验 致力于跨学科的合作，并提供明确的建议。