Functional highly ordered mesoporous phosphate glasses prepared by sol-gel

溶胶-凝胶法制备功能性高度有序介孔磷酸盐玻璃

• 批准号: 1976273
• 金额: --
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1976273
• 关键词: Functional; highly; ordered; mesoporous; phosphate

Aims:- To produce porous phosphate glass materials via the sol-gel route for the use in biomedical applications. The porosity will allow for drug loading and release.- To explore other soft-chemistry routes to produce phosphate glasses.- To explore different glass compositions by incorporating various metal ions into the glasses such as silver, copper and zinc. Many metal ions have been shown to play important roles in the wound healing and bone-production mechanisms and other ions such as silver have been presented as possessing antibacterial properties.- To study the physical and chemical properties of glasses produced such as biocompatibility, antibacterial properties, dissolution, strength and chemical stability.Methodology:- Produce glasses with pores on the nanoscale with the use of surfactants as templating agents. The surfactants will be removed after production leaving pores.- Porous scaffolds will be produced with the use of electrospinning. This will allow for a larger surface area and higher drug-loading capacities.

目标：- 通过溶胶-凝胶途径生产多孔磷酸盐玻璃材料，用于生物医学应用。孔隙率将允许药物装载和释放。-探索生产磷酸盐玻璃的其他软化学路线。-通过将各种金属离子（如银、铜和锌）掺入玻璃中来探索不同的玻璃成分。许多金属离子已被证明在伤口愈合和骨骼生成机制中发挥着重要作用，而其他离子（例如银）已被证明具有抗菌特性。- 研究所生产的玻璃的物理和化学特性，例如生物相容性、抗菌特性、溶解度、强度和化学稳定性。方法：- 使用表面活性剂作为模板剂生产具有纳米级孔隙的玻璃。生产后，表面活性剂将被去除，留下孔隙。 - 多孔支架将通过静电纺丝生产。这将允许更大的表面积和更高的载药能力。

项目成果

Phosphate-based glasses prepared via coacervation and sol-gel : synthesis and characterization

通过凝聚和溶胶-凝胶制备的磷酸盐玻璃：合成和表征

• 发表时间: 2022
• 作者: Kyffin Benjamin Alexander

Multifunctional phosphate-based glass fibres prepared via electrospinning of coacervate precursors: controlled delivery, biocompatibility and antibacterial activity

• DOI: 10.1016/j.mtla.2020.100939
• 发表时间: 2020-12-01
• 期刊: MATERIALIA
• 影响因子: 3.4
• 作者: Foroutan, Farzad;Nikolaou, Athanasios;Carta, Daniela
• 通讯作者: Carta, Daniela