DEVELOPMENT OF SKIN FLAP THERAPY DEVICE

皮瓣治疗装置的开发

• 批准号: 6292389
• 负责人: Patrick S Cottler
• 金额: $ 10万
• 依托单位: COTTLER TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6292389
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood coagulation; consumable /disposable biomedical equipment; electrical property; skin

DESCRIPTION (Verbatim From Applicant's Abstract):Development of a mechanical skin flap therapy device is proposed for the removal of stagnated blood and generation of blood flow within congested skin flaps to promote survival. Venous congestion is defined as a patent arterial inflow with compromised venous outflow in skin flaps, and has a 10 percent occurrence rate. Preliminary data shows multiple mechanically made outlets are as effective as leeches in alleviating venous congestion. With this data and an understanding of the beneficial mechanisms of leech therapy, a micro-mechanical, disposable device was designed to mimic these mechanisms while eliminating the drawbacks. The device design comprises a self-contained vacuum pump, based upon an innovative lightweight actuator, sharp outlets to puncture the skin and draw fluid from the flap, and an on-board battery power supply. Optimizing the actuator to maximize displacement while minimizing power is important to a successful design. Such a device would be utilized clinically like a leech to alleviate venous congestion and prophylactic treatments averting potential congestion. Leeches are currently not applied for prophylaxis. the long-term goal is to increase the success rate of skin flaps through commercial availability of this micro-device for interventional fluid transport from congested flaps. PROPOSED COMMERCIAL APPLICATION: There are approximately 1,000,000 procedures performed in the United States that potentially require the use of skin flaps. For treatment of venous congested flaps, over 70,000 leeches are currently sold to plastic surgery clinics annually, but they are only utilized upon serious, advanced indications of venous congestion. With the development of a small device that mimics the leech available off the shelf, that market could easily grow to three times that amount (see pages MARKET RESEARCH discussion), while also enhancing the overall success rate of skin flap transfer procedures. With the proposed device, the existing drawbacks to leech therapy would be eliminated thus making the mechanical leech a viable alternative in this market for patients, health care providers, and insurance companies.

描述（逐字摘自申请人的摘要）：机械的开发 皮瓣治疗装置被提议用于清除停滞的血液和 在充血的皮瓣内产生血流以促进存活。 静脉充血被定义为动脉血流畅通无阻 皮瓣静脉流出，发生率为 10%。初步的 数据显示，多个机械制造的插座与水蛭一样有效 缓解静脉充血。有了这些数据并了解 水蛭疗法（一种微型机械一次性装置）的有益机制 旨在模仿这些机制，同时消除缺点。这 设备设计包括一个独立的真空泵，基于创新的 轻质执行器，锋利的出口可刺穿皮肤并从中吸取液体 襟翼和机载电池电源。优化执行器 最大化排量同时最小化功率对于成功非常重要 设计。这种装置在临床上将像水蛭一样用于缓解 静脉充血和预防性治疗以避免潜在的充血。 水蛭目前不用于预防。长期目标是 通过商业可用性提高皮瓣的成功率 用于从充血皮瓣进行介入液体输送的微型装置。 拟议的商业应用： 在美国大约进行了 1,000,000 例手术 可能需要使用皮瓣。 用于治疗静脉充血皮瓣，超过 目前每年有 70,000 只水蛭出售给整形外科诊所，但它们仅 在严重、晚期静脉充血迹象时使用。随着发展 模仿现成的水蛭的小型设备，这个市场很容易增长 到该金额的三倍（参见市场研究讨论页），同时还 提高皮瓣转移手术的整体成功率。随着提议的 设备，水蛭疗法现有的缺点将被消除，从而使 机械水蛭是该市场上患者、医疗保健提供者、 和保险公司。