Low-Cost Sprayable Barrier for the Prevention of Surgical Adhesions

用于预防手术粘连的低成本可喷涂屏障

基本信息

批准号：
8454676
负责人：
Patrick S Cottler
金额：
$ 19万
依托单位：
LUNA INNOVATIONS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-02-15 至 2014-02-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8454676
关键词：
Abdomen Abdominal Cavity Accounting Address Adhesions Alginates Animal Model Animals Biocompatible Biopolymers Chitosan Clinical Complex Crosslinker Data Day Care Development Distal Drug Delivery Systems Drug Formulations Dyes Ensure Expenditure Female infertility Film Gel Government Healed Health Hospitals Imagery In Vitro Individual Infertility Injury to Peritoneum Inpatients Intestinal Obstruction Intra-abdominal Left Liquid substance Longevity Marketing Methods Nature Operative Surgical Procedures Peritoneum Persons Phase Postoperative Period Prevention Prevention approach Procedures Property Research Risk Series Site Small Intestines Solid Solutions Surface Surgical incisions System Technology Testing Thick Tissues United States Water Wound Healing biomaterial compatibility chemical property clinically significant cost experience healing in vitro testing in vivo injured innovation migration physical property prevent programs prototype public health relevance

项目摘要

DESCRIPTION (provided by applicant): Adhesion formation after intra-abdominal surgery poses a significant health risk, cited as a leading cause of small bowel obstruction and female infertility. Methods to prevent these adhesions are currently limited to barrier films which are difficult to place and are often restricted to use at the surgical incision site, leaving the bulk f the abdominal contents unprotected. To address this need, Luna Innovations proposes the development of a low-cost, sprayable barrier that will flow around and adhere to the internal tissues of the abdominal cavity, providing protection from adhesions for all internal surfaces during healing. Because of the nature of the components of this product, the proposed material will be biocompatible and biodegradable as it provides more complete protection than is available from currently marketed products. This program will focus on the refinement of the material components and delivery system to create the barrier formulations. Prototype formulations will undergo a series of in vitro characterization tests to assess their ability to effectively serve as a barrier to adhesion formation. The efficacy of the most promising formulations will be assessed in vivo.

描述（由申请人提供）：腹腔内手术后形成的粘连会带来重大的健康风险，被认为是小肠梗阻和女性不孕的主要原因。目前防止这些粘连的方法仅限于难以放置的屏障膜，并且通常仅限于在手术切口部位使用，从而使大部分腹部内容物不受保护。为了满足这一需求，Luna Innovations 建议开发一种低成本、可喷涂的屏障，该屏障将在腹腔内部组织周围流动并粘附在腹腔内部组织上，从而在愈合过程中防止所有内表面粘连。由于该产品成分的性质，所提议的材料将具有生物相容性和生物可降解性，因为它提供比目前市售产品更全面的保护。该计划将重点关注材料成分和输送系统的改进，以创建屏障配方。原型配方将进行一系列体外表征测试，以评估其有效作为粘附形成屏障的能力。最有希望的制剂的功效将在体内进行评估。