Local Profound Hypothermia in Intracranial Hemorrhage

颅内出血局部深度低温

• 批准号: 6485398
• 负责人: DONALD J LARNARD
• 金额: $ 14.97万
• 依托单位: SEACOAST TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2004-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6485398
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; blood coagulation; cerebral hemorrhage; cerebral ischemia /hypoxia; cryosurgery; cryotherapy; histology; induced hypothermia; intracranial hematoma; intubation; nonhuman therapy evaluation; polymers; skull; swine

DESCRIPTION (provided by applicant): In most hemorrhagic strokes, cerebral vessels may bleed into brain tissue producing an intracranial hemorrhage (ICH). The presence of clot causes irritation of brain tissue, causing ischemia, necrosis, and edema. Currently, there is very little treatment available to a patient with ICH. Hypothermia treatment, as with whole body hypothermia, is impractical and involves significant complications. We propose to use local, profound hypothermia (15-18 C) to teat such ICH insults. This involves placement of a cooling device through a burr hole and coolinga local region of brain near the ICH to profound hypothermia levels. ICH occurs in about 85,000 cases in the US annually with poor outcomes: 58 percent of patients die within 30 days, while the majority of survivors suffer major neurological deficits. In Phase I, prototype devices will be designed, built, tested in vitro and used in a porcine animal model of ICH to test for efficacy. Functional assessment, histological measurements as well as imaging methods will be used. In clinical practice, the devices would allow for treatment of ICH patents in lobar hemorrhages, which make up about 40 percent of all ICH.

描述（由申请人提供）：在大多数出血性中风中，脑卒中 血管可能会渗入脑组织，导致颅内出血 (ICH)。 凝块的存在会刺激脑组织，导致缺血， 坏死、水肿。目前，可用于治疗的药物非常少 脑出血患者。亚低温治疗与全身亚低温治疗一样， 不切实际并且涉及严重的并发症。我们建议使用本地、 深度低温（15-18℃）以应对此类 ICH 侮辱。这涉及到 通过钻孔放置冷却装置并冷却局部区域 靠近 ICH 的大脑达到极低体温水平。约 85,000 例 ICH 发生 美国每年都有预后不良的病例：58% 的患者在 30 天，而大多数幸存者患有严重的神经功能缺损。在 第一阶段，原型设备将被设计、建造、体外测试并用于 ICH 猪动物模型以测试功效。功能评估， 将使用组织学测量以及成像方法。在临床上 在实践中，这些设备将允许治疗脑叶中的 ICH 专利 出血，约占所有 ICH 的 40%。