Local Circuits & Direction Selectivity in Visual Cortex

本地电路

• 批准号: 6438923
• 负责人: DAVID FITZPATRICK
• 金额: $ 32.76万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2007-01-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6438923
• 关键词: behavioral /social science research tag; electrophysiology; eye movements; ferrets; image processing; intercellular connection; motion perception; neural information processing; neuroanatomy; neurons; single cell analysis; visual cortex; visual fields; visual perception; voltage /patch clamp

DESCRIPTION (From the Applicant's Abstract): This project proposes using the techniques of optical imaging and single unit recording to analyse the substrates for direction specificity in primary visual cortex of the ferret. The issue raised is that the various aspects of single moving objects present conflicting cues as to the direction of its motion (e.g. as illustrated by motion of contours in an aperture, or the barber pole illusion).Yet the visual system resolves these differences to predict an overall direction of motion and an accurate guide to eye movements. The proposed studies examine in detail the neuron population responses in V1 (by optical imaging) to movement of both oriented contour motion and the terminations of the same contour (which may be equated with dot motion). The experiments test the hypothesis that the perceived direction of motion is a weighted sum of the responses to the different directions of motion present in the stimulus. This sum can be affected by length of contour, contrast and speed. Single unit recording will be used to test the properties of single neurons at different points in the optical maps, to verify the map predictions, to test for variability of responses at single points, to test spatial interactions between terminal point and contour driven activity, and, together with voltage sensitive dye imaging, to examine differences in temporal evolution of signals from terminators and contours.

描述（摘自申请人的摘要）：该项目建议使用 光学成像和单个单元记录的技术来分析 在雪貂的一级视觉皮层中的方向特异性的底物。 提出的问题是，存在的单个移动对象的各个方面 关于其运动方向的提示相抵触（例如 孔中的轮廓运动或理发杆幻觉）。 系统解决了这些差异，以预测运动的总体方向和 精确的眼睛运动指南。拟议的研究详细研究了 V1中的神经元种群反应（通过光学成像）对两者的运动 定向轮廓运动和相同轮廓的终止（可能是 等同于点运动）。实验检验了以下假设 感知的运动方向是对响应的加权总和 刺激中存在的不同运动方向。这笔款项可以是 受轮廓，对比度和速度的长度影响。单个单元记录将 用于测试单个神经元在不同点的特性 光学图，以验证地图预测，以测试 单点的响应，以测试终端点之间的空间相互作用 和轮廓驱动的活动，以及电压敏感的染料成像， 检查终止者信号的时间演变差异和 轮廓。