Neural instructive signals in the cerebellum

小脑中的神经指导信号

• 批准号: 7123450
• 负责人: Michael C Ke
• 金额: $ 3.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2007-09-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123450
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; biological signal transduction; cell population study; cerebellar Purkinje cell; electrophysiology; eye movements; head movements; learning; motor neurons; neural information processing; neural plasticity; neuron component; neuropsychology; predoctoral investigator; psychomotor function; single cell analysis; vestibuloocular reflex; visual tracking

DESCRIPTION (provided by applicant): Motor learning is a set of processes that leads to a long-lasting adaptive change in an individual's capability to perform a movement. One brain structure necessary for motor learning is the cerebellum, however there are two competing theories regarding its role in learning. One theory contends the cerebellum is the site of learning and memory storage, whereas another argues that the cerebellum computes an instructive signal to mediate learning events outside the cerebellum. This long-standing debate can be resolved by examining what neural signals are available in the cerebellum to induce motor learning in an awake, behaving animal. If the cerebellum computes an instructive signal, then patterns of neural activity in the output neurons of the cerebellum (Purkinje cells) should be correlated to the learned changes. Likewise, if the cerebellum is the site of learning, one set of cerebellar input neurons (climbing fibers) should contain the necessary information to guide learning. Therefore, we propose recording Purkinje cells and climbing fibers during a motor learning task, adaptation of the vestibulo-ocular reflex. We will then ask does the direction of learning best correlate with the direction and amplitude of Purkinje cell or climbing fiber responses?

描述（由申请人提供）：运动学习是一组过程，可导致个人执行运动能力的持久自适应变化。运动学习所需的一种大脑结构是小脑，但是关于其在学习中的作用有两种相互竞争的理论。一种理论认为，小脑是学习和记忆存储的站点，而另一个小脑则认为小脑会计算一个有指导的信号来介导小脑外的学习事件。可以通过检查小脑中有哪些神经信号来解决这种长期存在的辩论，以在醒着，表现动物中诱导运动学习。 如果小脑计算一个指导性信号，则应将小脑输出神经元（Purkinje细胞）中神经活动的模式与学习的变化相关。同样，如果小脑是学习的站点，则一组小脑输入神经元（攀岩纤维）应包含指导学习的必要信息。因此，我们建议在运动学习任务期间记录浦肯野细胞和攀爬纤维，并适应前庭 - 眼反射。然后，我们将问学习方向是否与浦肯野细胞的方向和振幅相关或攀登纤维反应？