RENOVATION OF THE ULLMANN ANIMAL UNIT

乌尔曼动物单元的翻新

• 批准号: 2558178
• 负责人: Diane J. GAERTNER
• 金额: $ 59.89万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-18 至 2001-05-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2558178
• 关键词: animal care; animal colony; biomedical equipment purchase; biomedical resource; building /facility design /renovation

In this revised submission, matching funds are requested to renovate the Ullmann Animal Unit of the Albert Einstein College of Medicine, a major biomedical research institution with more than 44 million dollars in PHS funding. The Ullmann Animal Unit of 16,400 net square feet includes the 10th and 11th floors of the Ullmann building and house approximately half of AECOM's research animals, supporting more than 60 investigators and most major research programs of the college. The objective are (1) to convert largely unused dog rooms to additional barrier rodent space and more flexible space, (2) to improve the control of airflow and formite- borne rodent pathogens in rooms and hallways, (3) to improve cage sanitization, (4) to remove heat and humidity generated by cage washing, (5) to better vent exhaust anesthetic gasses, (6) to control temperature for Xenopus frogs, (7) to remove windows from animal rooms, and (8) to increase housing for pathogen-free mice. These objectives will be met by a 4-part renovation plan. In Part A, six large rooms will be renovated to create two barrier rodent suites and two multi-species rooms. The barrier rodent suites will be used to re-derive and re-stock the Ullman Building with pathogen-free rodents. The multi-species rooms will flexibly house small numbers of dogs, pigs, or sheep. In Part B, the cage-wash will be expanded to store dirty cages, the antiquated tunnel and rack washers will be replaced and the room exhaust will be upgraded. A new fume hood will be installed to vent waste anesthetic gasses from a heavily-used procedure room. In Part C, in-room supplemental cooling and new caging will be purchased to permit optimal housing and natural breeding of Xenopus frogs by providing temperatures under 72 degrees F. In Part D, 120 windows in 31 animals rooms on two floors will be eliminated to permit photoperiod control and to increase energy efficiency. This set of 4 related renovations will permit much-needed expansion of pathogen-free housing for rodents, including increasing numbers of immunodeficient, transgenic and knock-out mice in both the Ullman and Chanin buildings. These renovations are urgently needed and will assure compliance with the USDA Animal Welfare Act and DHHS policies related to room temperatures, controlling lighting and ventilation, working conditions for animal caretakers. The renovations will also assist us in maintaining our AAALAC accreditation.

在这份修订后的提交文件中，要求配套资金用于翻修 阿尔伯特·爱因斯坦医学院的乌尔曼动物单位，一个专业 PHS超过4400万美元的生物医学研究机构 资金。乌尔曼动物单元占地 16,400 净平方英尺，包括 Ullmann大楼的10层和11层以及大约一半的房屋 AECOM 的研究动物，支持 60 多名研究人员和 学院最重要的研究项目。目标是 (1) 将大部分未使用的狗房改造成额外的屏障啮齿动物空间， 更灵活的空间，（2）改善对气流和蚁群的控制 在房间和走廊传播啮齿动物病原体，（3）改善笼舍 消毒，（4）去除笼子清洗产生的热量和湿气， (5) 更好地排出麻醉气体，(6) 控制温度 对于非洲爪蟾，(7) 拆除动物房的窗户，以及 (8) 增加无病原体小鼠的住房。这些目标将通过 一个由 4 部分组成的改造计划。 A部分将改造六间大房间 创建两间屏障啮齿动物套房和两间多物种房间。障碍 啮齿动物套件将用于重新衍生和补充乌尔曼大楼 与无病原体的啮齿动物。多品种房间将灵活容纳 少量的狗、猪或羊。在 B 部分中，笼子清洗将是 陈旧的隧道式和架式洗衣机扩大用于存放脏笼子， 更换，房间排气升级。一个新的通风柜将 安装用于排出频繁使用的手术中产生的麻醉废气 房间。在 C 部分，室内补充冷却和新的笼子将 购买是为了实现非洲爪蟾的最佳居住和自然繁殖 通过提供低于 72 华氏度的温度。在 D 部分中，31 个窗户中有 120 个窗户 两层楼的动物房将被取消，以允许光照 控制并提高能源效率。这组4个相关 翻修将允许扩大急需的无病原体住房 啮齿动物，包括数量不断增加的免疫缺陷、转基因和 厄尔曼和查宁大楼中的基因敲除小鼠。这些装修 迫切需要并将确保符合美国农业部动物法规 福利法和 DHHS 与室温相关的政策，控制 照明和通风，动物看护者的工作条件。这 翻新工程还将帮助我们维持 AAALAC 认证。