ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT

动物资源设施设备改造工程

• 批准号: 6758759
• 负责人: GEORGE L KING
• 金额: $ 65万
• 依托单位: JOSLIN DIABETES CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2006-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6758759
• 关键词: animal care; animal colony; biomedical equipment purchase; biomedical equipment resource; building /facility design /renovation

DESCRIPTION (provided by applicant): The Joslin Diabetes Center is committed to the continued improvement of its animal care and use program. Recently completed renovations have greatly improved animal care by providing improvements in the physical plant, cage wash capabilities and animal housing. The addition of a full time Veterinarian Director has also strengthened the program, especially with regards to animal health, protocol development and fiscal stability. This improvement project will support the efforts of the Joslin Diabetes Center to continue the process of providing investigators with a quality research resource by enhancing animal welfare and the efficient operation of the animal facility. The described aims request additional PIV mouse racks, upgrading static murine micro-isolation cages, a full micro-isolation system for rats, a water purification system for all drinking water, and a laminar flow work station for a procedure room. Rats and mice are the only species housed in the Joslin Diabetes Center animal facility and the above improvements will impact their welfare by providing greater biosecurity, higher quality water, a healthier microenvironment for the animals and macrooenvironment for personnel, and static cages which allow animals to be more easily monitored. Aggressive pursuit of the short-term goals of improving animal care is critical to achieving the long-term goal of AAALAC; International accreditation. The research program at the Joslin Diabetes Center has experienced significant expansion and is expected to continue this trend due to the current epidemic of Type II diabetes. Animal models, primarily murine, have been enormously expanded as a result of the powerful tools of transgenic and knockout technologies. Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program.

描述（由申请人提供）： 乔斯林糖尿病中心致力于持续改进其动物护理和使用计划。最近完成的翻修工程通过改善物理设施、笼子清洗能力和动物圈舍，极大地改善了动物护理。全职兽医主任的加入也加强了该计划，特别是在动物健康、方案制定和财政稳定方面。该改进项目将支持乔斯林糖尿病中心的努力，通过提高动物福利和动物设施的高效运营，继续为研究人员提供优质研究资源。所述目标需要额外的 PIV 小鼠架、升级静态小鼠微隔离笼、用于大鼠的完整微隔离系统、用于所有饮用水的水净化系统以及用于手术室的层流工作站。大鼠和小鼠是乔斯林糖尿病中心动物设施中饲养的唯一物种，上述改进将通过提供更好的生物安全、更高质量的水、更健康的动物微环境和人员宏观环境以及允许动物活动的静态笼子来影响它们的福利。更容易被监控。积极追求改善动物护理的短期目标对于实现 AAALAC 的长期目标至关重要；国际认证。 Joslin 糖尿病中心的研究项目经历了显着的扩展，并且由于当前 II 型糖尿病的流行，预计将继续这一趋势。由于转基因和基因敲除技术的强大工具，动物模型（主要是小鼠）已得到极大扩展。所要求的改进不仅会影响动物福利，而且还将有利于研究动物计划的效率。