MRI-Based Virtual Bone Biopsy

基于 MRI 的虚拟骨活检

• 批准号: 6577620
• 负责人: Felix W Wehrli
• 金额: $ 37.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577620
• 关键词: bioimaging /biomedical imaging; biomechanics; bone density; bone disorder; bone fracture; bone imaging /visualization /scanning; clinical research; diagnosis design /evaluation; female; human old age (65+); human subject; image processing; magnetic resonance imaging; musculoskeletal disorder diagnosis; noninvasive diagnosis; osteoporosis; patient oriented research; photon absorptiometry; substantia spongiosa

DESCRIPTION (provided by applicant): The poor correlation between fracture prevalence and bone mineral density has spurred the search for other parameters affecting the bone's mechanical competence. Although it has generally been assumed that the bone's intrinsic material properties remain unaltered in osteoporosis, there is strong evidence that this may not be the case. Specifically, the question has arisen whether parameters over and beyond material density, often summarized under the term "bone quality", may affect the bone's resistance to failure. Among the contributors conjectured to confer strength to bone, the structure of the trabecular network has received the greatest attention. Most prior work is based on histomorphometry or imaging of biopsy specimens. However, bone biopsy, because of its invasive nature, is usually not clinically indicated. In this project it is proposed to further develop and clinically evaluate the virtual bone biopsy, conceived in the investigators' laboratory, for assessing trabecular network integrity. The method is based on in vivo magnetic resonance microscopy (IMRI) and involves acquisition of 3D images of a representative volume comprising trabecular bone and marrow at a peripheral surrogate site (distal radius, distal tibia, calcaneus) and at a resolution sufficient to resolve the structural elements. The images are then subjected to a cascade of image restoration and processing steps yielding complete quantitative characterization of the trabecular bone network's three-dimensional topological make-up and scale. Prior work in the investigators' laboratory demonstrates that mu-MRI-derived architectural parameters are strong predictors of the bone's stiffness and provide a detailed picture of the etiology of postmenopausal osteoporotic bone loss, which is a conversion of trabecular plates to rods and disruption of rods. The overall hypothesis of this proposal is that the mu-MRI-based in vivo virtual bone biopsy provides detailed quantitative insight into the architectural implications of bone loss and that it discriminates patients with vertebral fractures from their gender and bone mineral density matched peers.

描述（由申请人提供）：断裂患病率与骨矿物质密度之间的较差相关性促使人们寻找影响骨骼机械能力的其他参数。尽管通常假定骨骼的内在材料特性在骨质疏松症中仍然没有改变，但仍有强有力的证据表明可能并非如此。具体而言，问题是出现的问题是否超过材料密度（通常以“骨质””为总结的材料密度是否会影响骨骼对失败的抵抗力。在猜想赋予骨骼强度的贡献者中，小梁网络的结构受到了最大的关注。大多数先前的工作是基于组织形态法或活检标本的成像。然而，由于其侵入性性质，骨骼活检通常在临床上没有表明。在该项目中，建议进一步开发和临床评估研究人员实验室中构想的虚拟骨活检，以评估小梁网络完整性。该方法基于体内磁共振显微镜（IMRI），涉及在外围替代位点（远端半径，胫骨，卡明基）和足够解决结构元素的分辨率的外围替代位点（远端半径，远端，胫骨）的代表体积的3D图像。然后，将图像经过一系列图像恢复和处理步骤进行级联，从而对小梁骨网络的三维拓扑组成和尺度进行完全定量表征。研究人员实验室的先前工作表明，Mu-Mri衍生的建筑参数是对骨骼僵硬度的有力预测指标，并提供了绝经后骨质疏松骨质损失的病因，这是小径板转化为杆向杆和杆的破坏。该提议的总体假设是，基于MU-MRI的体内虚拟骨活检对骨质流失的建筑意义提供了详细的定量洞察力，并且它将椎骨骨折患者与性别和骨矿物质密度相匹配的患者区分开来。