SENSORY REGULATION OF ADULT NEUROGENESIS

成人神经发生的感觉调节

• 批准号: 6476038
• 负责人: CAROLYN Liv PYTTE
• 金额: $ 3.68万
• 依托单位: WESLEYAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6476038
• 关键词: auditory stimulus; cell proliferation; cell senescence; cochlea; electrophysiology; neurogenesis; neurons; postdoctoral investigator; sensory deprivation; songbirds

Bilateral cochlea removal alters neuronal turnover in the adult avian song system in regions underlying singing behaviors. The goals of the proposed research are 1) to identify the processes of neuronal turnover that are affected by cochlea removal and 2) to determine whether these cellular effects are due to sensory deprivation, specifically the absence of song-related auditory stimulation. Deafening may prolong neuron survival. By altering the timing of deafening and cell birthdating, we will evaluate the effects of deafening on new neuron survival. Deafening may also either decrease cell proliferation or decrease neuron survival during the first few weeks after formation. The proposed experiments will discern between these two hypotheses. Neurons that undergo replacement are found in a region that increases spiking activity in response to song-related auditory stimulation. By blocking song-related auditory stimulation in hearing birds we will determine whether song- related auditory deprivation is responsible for the effects of bilateral cochlear removal. Because neuronal activity is tightly linked to the complex, learned, behavior of song production, the relationship between auditory experience, cell turnover, and behavior can be well characterized in this system. The goal of this research is to identify the normal sensory requirements for regulating neuronal replacement. Insight into mechanisms regulating adult neurogenesis, incorporation, and cell death may be expected to contribute to our understanding of the basic rules governing the maintenance, modification, and perhaps repair of neural circuits. This research may ultimately prove useful in designing strategies to repair the adult human brain.

双边耳蜗的去除会改变成年鸟类歌曲系统的神经元转移，在唱歌行为的区域中。拟议的研究的目标是1）确定受耳蜗去除影响的神经元周转过程和2）确定这些细胞效应是否是由于感觉剥夺引起的，特别是缺少与歌曲相关的听觉刺激。震耳欲聋可能会延长神经元的存活。通过改变震耳欲聋和细胞生育的时间，我们将评估聋哑人对新神经元存活的影响。在形成后的头几周，震耳欲聋的人也可以减少细胞增殖或降低神经元的存活。提出的实验将辨别这两个假设。在响应与歌曲相关的听觉刺激的区域中发现了进行替换的神经元。通过阻止听觉鸟类中与歌曲相关的听觉刺激，我们将确定与歌曲相关的听觉剥夺是否导致双边耳蜗去除的影响。因为神经元活动与复杂的，学习的歌曲产生行为紧密相关，因此在该系统中可以很好地表征听觉经验，细胞更新和行为之间的关系。这项研究的目的是确定调节神经元置换的正常感觉要求。可以预期，可以洞悉调节成人神经发生，掺入和细胞死亡的机制，这有助于我们理解有关​​维持，修改以及可能修复神经回路的基本规则。这项研究最终可能证明可用于设计修复成年人大脑的策略。