New Non-invasive Imaging Methods For Biomedical Applicat

生物医学应用的新型非侵入性成像方法

• 批准号: 6541712
• 负责人: HAN WEN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6541712
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; heart contraction; heart imaging /visualization /scanning; heart motion; human subject; magnetic resonance imaging; noninvasive diagnosis; patient oriented research; technology /technique development

In the last year we focused our effot and made progress in the area of quantitative contractile function assessment of the human heart in vivo. Based on the stimulated-echo phase contrast method DENSE, which was proposed for micro-imaging and applied successfully in the human heart by our group,we optimized the technique for single breath-hold in vivo application in patients. Using a state-of-the-art 1.5 tesla whole-body clinical scanner, the technology is now able to quantify the motion of the entire left ventricular wall in three-dimensional space in a breath-hold of 15 heartbeats. For other cardiac MRI exams that need more than a breath-hold, we developed a motion-navigator technique that tracks the actual position of the heart from beat to beat, with improved reliability for individual patients than diaphragm based methods. With this method, many exams can be reliably performed under normal breathing condition. We also demonstrated a novel vectorized motion imaging method that may have interesting applications in small animal MRI.

在去年，我们集中精力，并在体内对人心脏的定量收缩功能评估领域取得了进展。基于刺激的回波相对比方法密度，该方法是为微成像提出的，并由我们的组成功地应用于人类心脏，我们优化了患者中单次呼吸含量的技术。该技术使用最先进的特斯拉全身临床扫描仪，现在能够在三维空间中以15个心跳的呼吸量化整个左心室壁的运动。对于其他需要超过呼吸的心脏MRI考试，我们开发了一种运动范围的运动技术，该技术从Beat到Beat跟踪心脏的实际位置，对个别患者的可靠性比基于隔膜的方法的可靠性提高。使用这种方法，许多考试可以在正常的呼吸条件下可靠地进行。我们还展示了一种新型的矢量化运动成像方法，该方法可能在小动物MRI中具有有趣的应用。