FUNCTIONAL ORGANIZATION OF HUMAN PRIMARY MOTOR CORTEX

人类初级运动皮层的功能组织

• 批准号: 6477606
• 负责人: NANCY L Sicotte
• 金额: $ 4.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477606
• 关键词: bioimaging /biomedical imaging; biomedical resource; child (0-11); cognition; communication behavior; computers; female; genetics; magnetic resonance imaging; male; mental disorders; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

This project is a family genetic stud), comparing childhood onset schizophrenia and attention deficit hyperactivity disorder. The objective of this study is to identify genes associated with different facets of the schizophrenia phenotype. Specific Aims 1. To determine the rate of schizophrenia and Schizophrenic Spectrum Personality Disorder (SSPD) by direct interviews of first degree relatives, and by family history for second degree relatives, of children with onset of schizophrenia prior to thirteen years of age. To compare the rates of schizophrenia and SSPD among the first and second degree relatives of schizophrenic children to those observed in children with ADHD and normal control children. 2. To test the hypothesis that certain attention and information processing (AIP) Impairments index a genetic liability to schizophrenic disorder by determining if there is an increased aggregation of certain impairments among the first degree relatives of schizophrenic children as compared to the first degree relatives of children with ADHD and normal control children. 3. To replicate findings that schizophrenic probands have reduced total cerebral volume and reductions in the volume of the midsagittal thalamic area which exceeds the reduction in total cerebral volume, and enlargements of the caudate and putamen. 4. To identify genes associated with the presence of schizophrenia, SSPD, AIP. impairments and changes in volumes of brain structures in schizophrenic probands and their siblings.

这个项目是一个家庭遗传螺柱），比较童年的发作 精神分裂症和注意力缺陷多动障碍。 这 这项研究的目的是确定与不同的基因 精神分裂症表型的方面。 具体目标 1。确定精神分裂症和精神分裂症的速度 人格障碍（SSPD）通过一级直接访谈 亲戚，以及二级亲戚的家族史 十三岁之前患有精神分裂症的儿童。 比较第一个和SSPD的速率 精神分裂症儿童的二级亲戚 患有多动症和正常对照儿童的儿童。 2。检验某些关注和信息的假设 处理（AIP）损害指数遗传负债 精神分裂症通过确定是否增加 在一级亲属之间的某些障碍的汇总 精神分裂儿童与一级亲戚相比 患有多动症和正常对照儿童的儿童。 3。复制发现精神分裂症的发现减少了 中大脑的总体积和减少体积 丘脑区域超过总脑体积减少的区域 以及尾状和壳壳的扩大。 4。确定与精神分裂症的存在相关的基因， SSPD，AIP。 障碍和大脑结构体积的变化 精神分裂症的概率及其兄弟姐妹。