GENE EXPRESSION PROGNOSIS & TRTMT RESPONSE STRATIFICATION IN PATS W/ GLIOMA

基因表达预测

• 批准号: 6477613
• 负责人: TIMOTHY CLOUGHESY
• 金额: $ 4.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477613
• 关键词: bioimaging /biomedical imaging; biomedical resource; child (0-11); communication behavior; computers; female; magnetic resonance imaging; male; mental disorders; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

Determine the neural networks involved in three aspects of nonverbal and social communication: affective prosody, perception of facial expression, and response to emotionally laden scenes. We examine each category of cognitive task from three levels to address the following questions. a. Perceptual: is the basic apparatus for visual and auditory perception of emotional, versus non-emotional, sensory information intact? b. affective; does perception of affect produce appropriate emotional arousal as evidenced by activation of emotion-mediated brain centers in the limbic circuit? c. executive: are the neural networks involved . in utilizing and making judgments about perceived and experienced affect intact? 2. Determine differences in these neural networks in higher functioning autistic individuals, which are specific to autism, in comparison to a non-autistic, language impaired population, along the following dimensions: a. regional dvsfunction: do autistic and control subjects differ in their ability to activate key brain regions associated with the above levels of processing? b. functional connectivity: do autistic and control subjects differ in the functional connections between critical brain regions, and how do these regions interact during task performance? c. anatomical underpinnings of specific symptons: can we identify regional and functional connectivity differences associated with specific symptoms of autism?

确定涉及三个方面的神经网络 非语言和社会交流：情感韵律，对 面部表情以及对情感上载有场景的反应。 我们 检查每个类别的认知任务从三个级别寻址 以下问题。 一个。感知：是视觉和听觉的基本设备 情感和非情感感官信息的感知 完好无损的？ b。情感；感知影响会产生适当的 情绪唤醒可以激活情绪介导的大脑 边缘电路中的中心？ c。执行：是神经网络 涉及 。 利用和做出对感知和的判断 经历的影响完好无损？ 2。确定这些神经的差异 较高功能的自闭症患者的网络 特定于自闭症，与非自动，语言受损相比 人口，沿以下维度：区域DVSFunction： 自闭症和控制受试者的激活能力有所不同 与上述处理水平相关的关键大脑区域？ b。 功能连接：自闭症和控制对象在 关键大脑区域之间的功能连接以及如何 这些区域在任务执行过程中相互作用？ c。解剖学 特定症状的基础：我们可以识别区域和 功能连通性差异与特定症状有关 自闭症？