ONSET OF PROGRESSIVE MS STRUCTURAL & FUNCTIONAL DETERMINANTS

发生进行性结构性多发性硬化症

• 批准号: 8171033
• 负责人: NANCY L Sicotte
• 金额: $ 1.22万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171033
• 关键词: Atrophic; Clinical; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Enhancing Lesion; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Institution; Internal Capsule; MRI Scans; Measures; Monitor; Motor; Myelin; Neurons; Pathway interactions; Patients; Research; Research Personnel; Resources; Source; Spectrum Analysis; Techniques; Time; Tissues; United States National Institutes of Health; brain pathway; disability; novel; theories; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate the structural and functional changes that occur within specific pathways of the brain in MS patients. These measures will be compared over time to determine the relationship between anatomical and functional changes and clinical measures of progression. Serial MRI scans will be used to measure changes in tissue integrity over a period of 3 years, at 6 month intervals. Novel structural techniques (magnetization transfer imaging (MTI), diffusion tensor imaging (DTI), atrophy measures and spectroscopy) will be used to monitor changes within specific tissue compartments and white matter pathways. (ie MTI P myelin, NAA spectroscopy P neurons, DTI P internal capsule, corpus callosum). Traditional structural measures (enhancing lesions, T2 burden) will be obtained as well for comparison. Serial functional MRI of motor and cognitive tasks will be obtained at the same time points to determine if functional disintegration is an important factor in progre ssive disability as would be predicted by the threshold theory.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是评估MS患者大脑特定途径内发生的结构和功能变化。随着时间的流逝，将比较这些措施，以确定解剖学和功能变化与进展的临床度量之间的关系。串行MRI扫描将在3年的时间内以6个月的间隔来测量组织完整性的变化。新型结构技术（磁化转移成像（MTI），扩散张量成像（DTI），萎缩度量和光谱法）将用于监测特定组织隔室内的变化和白质途径。 （即MTI P髓素，NaA光谱P神经元，DTI P内胶囊，call体）。还将获得传统的结构措施（增强病变，T2负担）以进行比较。将在同一时间点获得运动和认知任务的串行功能MRI，以确定功能分解是否是进展残疾的重要因素，就像阈值理论所预测的那样。