MOVEMENT ORGANIZATION DYSFUNCTION IN PARKINSONS

帕金森病患者的运动组织功能障碍

• 批准号: 6529450
• 负责人: GEORGE E. STELMACH
• 金额: $ 30.5万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529450
• 关键词: Parkinson's disease; biomechanics; body movement; clinical research; functional ability; human subject; levodopa; neural information processing; proprioception /kinesthesia

While advances in Parkinson's disease have been established in recent years, the pathogenesis of the disease is still not well understood. The primary goal of this project is to quantify how complex multijoint movement is impaired in Parkinsonian patients, thereby providing a better understanding of how motor control principles are compromised. Our working hypothesis concerning PD patients is that much of their difficulty with complex movements arises from their inability to coordinate body segments. We use a trunk-assisted prehension task and analyze trunk, arm, and aperture synchronization when speed, accuracy, sequencing of segments, and visual feedback constraints are imposed. We will analyze body segment synchronization, relative timing, spatial invariance, and synergies. Collectively, the results from these experiments will allow us to better understand how PD affects movement coordination patterns during the performance of complex actions. Comparisons of 'off' vs. 'on' states in Parkinson's disease patients may help determine if coordination impairments share a common levodopa basis. The experiments proposed are systematic, novel and use proven methodology. The proposed research should advance understanding of the fundamental principles that guide the coordination of multijoint movements in normal subjects. It will also increase understanding of the ways in which Parkinson's disease patients are restricted in the use of these principles. The results from four experiments should be useful to both the basic neuroscientist and clinical science communities, reducing the gap between fundamental knowledge of neural mechanisms and therapeutic intervention.

虽然近年来帕金森氏病的进步已经建立，但该疾病的发病机理仍未得到很好的了解。该项目的主要目的是量化帕金森患者中复杂的多关节运动受到损害的损害，从而更好地了解了如何妥协运动控制原理。 我们关于PD患者的工作假设是，他们在复杂运动方面的困难源于他们无法协调人体段。 当速度，准确性，段的测序和视觉反馈约束时，我们使用树干辅助的预性任务并分析躯干，臂和孔径同步。 我们将分析身体段同步，相对时机，空间不变性和协同作用。 总的来说，这些实验的结果将使我们能够更好地理解PD在复杂动作的表现过程中如何影响运动协调模式。 在帕金森氏病患者中对“ OFF”与“在”状态的比较可能有助于确定协调障碍是否具有共同的左旋多巴。 提出的实验是系统的，新颖的，并且使用了经过验证的方法。 拟议的研究应提高人们对指导正常受试者多关节运动协调的基本原则的理解。 它还将增加对帕金森氏病患者在使用这些原则中受到限制的方式的理解。 四个实验的结果对于基本的神经科学家和临床科学界都应该有用，从而减少了神经机制的基本知识与治疗干预之间的差距。