DEVELOPMENTAL TWIN STUDY: ATTENTION, AGGRESSION, AFFECT

双胞胎发育研究：注意力、攻击性、情感

• 批准号: 6528510
• 负责人: James J. Hudziak
• 金额: $ 32.24万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-29 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528510
• 关键词: adolescence (12-20); age difference; aggression; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child behavior; clinical research; comorbidity; depression; gender difference; gene environment interaction; human subject; longitudinal human study; mental health epidemiology; middle childhood (6-11); parent offspring interaction; preschool child (1-5); psychometrics; teacher; twin /multiplet

The main objective of this proposed twin study is to use data from multiple informants, obtained at multiple time points with multiple assessment techniques to identify heritable phenotypes for future gene-mapping studies of ADHD and related behaviors. To accomplish this objective, the investigator will analyze standardized parental reports of Attention Problems, Aggressive Behavior, and Anxious/Depressed behavior syndromes, as measured by the Child Behavior Checklist (CBCL) which have been shown to be highly predictive of ADHD and its most common comorbid conditions. CBCLs have been collected on 3,084 twin pairs by the Netherlands Twin Registry when they were 3 and 7 years old. To these data, he will add parent (CBCL and Parent Rating Scale- CPRS) and teacher reports (Teacher's Report Form- TRF, and Conners' Teacher Rating Scale-CTRS) at ages 10 and 12. He will also add maternal DSM-IV interview data on a sub-sample of 250 at high risk for ADHD and 250 non-ADHD twin pairs. This design has the following strengths: 1) It combines features of a twin study with those of a longitudinal design; 2) It adds teachers' report data to a study that previously had only parental report data; 3) It adds Conners' data to a study that previously only had CBCL data; 4) It collects DSM-IV data via interviews on a selected sample of the twins who have been well described with CBCL data at ages 3, 7, 10, and 12 and with TRF/Conners' data at ages 10 and 12. With these data, the investigator will achieve the following aims: 1) Test informant variance effects by combining mother, father, and teacher ratings; 2) Measure instrument variance by combining CBCL, Conners' and DSM Interview data to assess genetic correlation for symptoms of ADHD and related behaviors across assessment approaches; 3) Measure developmental continuity and change in genetic and environmental contributions to symptoms of ADHD and related behaviors; 4) Test gender differences in the genetic and environmental contributions to symptoms of ADHD and related behaviors; and 5) Use genetic latent structure models to estimate genetic and environmental influences on comorbidity of symptoms of ADHD and related behaviors. Potential benefits of this research include the identification of genetically discriminating phenotypes for the study of ADHD and related disorders. By identifying these phenotypes, this research will help guide future molecular genetic studies of ADHD and related behaviors. A long-term goal of this project is to continue to study these subjects in order to extend the study of genetic factors from childhood, across adolescence, and into adulthood.

这项拟议的双胞胎研究的主要目的是使用来自 多个线人，在多个时间点获得多次评估 识别可遗传表型的技术，用于未来的基因映射研究 多动症和相关行为。为了实现这一目标，调查人员将 分析关注问题的标准化父母报告，积极进取 由孩子衡量的行为和焦虑/沮丧的行为综合征 行为清单（CBCL）已显示为高度预测多动症 以及最常见的合并条件。 CBCL已在3,084上收集 3岁和7岁时，荷兰双胞胎注册表的双胞胎对。 在这些数据中，他将添加父级（CBCL和父评级量表-CPR）和 教师报告（教师报告Form-trf和Conners的教师评级 在10岁和12岁时的比例尺）。他还将添加孕产妇DSM-IV访谈数据 在ADHD高风险和250个非ADHD双对的250个子样本中。这 设计具有以下优势：1）它结合了双胞胎研究的功能 具有纵向设计的； 2）它将教师的报告数据添加到 以前只有父母报告数据的研究； 3）它添加了Conners的数据 进行以前仅具有CBCL数据的研究； 4）它通过 对经过很好描述的双胞胎的选定样本采访 CBCL的数据为3、7、10和12，并在10岁时使用TRF/Conners的数据 12。使用这些数据，研究人员将实现以下目的：1）测试 通过结合母亲，父亲和教师评级来效果的线人差异效果； 2） 通过组合CBCL，Conners和DSM面试数据来测量仪器差异 评估ADHD症状和相关行为的遗传相关性 评估方法； 3）衡量发展连续性和变化 对多动症及相关症状的遗传和环境贡献 行为； 4）测试遗传和环境的性别差异 对多动症症状和相关行为的贡献； 5）使用遗传 潜在结构模型估计遗传和环境影响 多动症症状和相关行为的合并症。潜在的好处 这项研究包括鉴定遗传区分的 多动症和相关疾病研究的表型。通过识别这些 表型，这项研究将有助于指导未来的分子遗传研究 多动症和相关行为。该项目的长期目标是继续 研究这些受试者，以扩大对遗传因素的研究 童年，整个青春期和成年。