Nanoprobes for Molecule-Specific Contrast Enhancement

用于分子特异性对比度增强的纳米探针

• 批准号: 6551178
• 负责人: LEYUN ZHU
• 金额: $ 10万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-02 至 2003-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6551178
• 关键词: Raman spectrometry; colloids; high energy particle; light scattering; molecular dynamics; nanotechnology; silver; technology /technique development; thiols

DESCRIPTION (provided by applicant): Development of nano-Raman probes that will facilitate the detection of Raman scattering of individual molecule is proposed. The proposed phase I research will focus on the rational design of a nanoparticle system and analyte-nanoparticle complex. The nanoparticle-solid state support platform will also be optimized in the proposed research. During the phase I research the feasibility of a strategy for analyzing single molecule vibrational spectrum in complex cellular system will be established. This research will lead to the development of a marketable analytical system with the capability of analyzing the structure of an individual molecule. We believe that the availability of a robust sensitive Raman system will have broad interest from chemical and biomedical researchers. And it might have impact on DNA sequencing, early stage disease detection, and environmental monitoring.

描述（由申请人提供）：提出了促进单个分子拉曼散射的纳米拉曼探针的开发。提出的I期研究将重点放在纳米颗粒系统和分析纳米颗粒复合物的合理设计上。纳米粒子 - 固定状态支持平台也将在拟议的研究中进行优化。在第一阶段研究中，将建立用于分析复杂细胞系统中单分子振动光谱的策略的可行性。这项研究将通过分析单个分子的结构的能力，导致可销售的分析系统的发展。我们认为，强大的敏感拉曼系统的可用性将引起化学和生物医学研究人员的广泛兴趣。它可能会影响DNA测序，早期疾病检测和环境监测。