BOMBESIN BB4 RECEPTORS

铃蟾肽 BB4 受体

• 批准号: 6453685
• 负责人: ELIOT R SPINDEL
• 金额: $ 11.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6453685
• 关键词: Chordata; Mammalia; animal tissue; biotechnology; endocrine gland /system; growth /development; hormones; inborn metabolism disorder; infant mortality; low birth weight infant human; mother /infant health care; respiratory system

The bombesin-like peptides comprise a large family of peptides originally characterized in amphibians, then later found to be widely distributed in mammals. CNS administration of bombesin to rats has potent effects on appetite, body temperature, grooming, heart rate, and GI function. Two mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been characterized to date. At present, three mammalian bombesin-like peptide receptors have been characterized; the GRP receptor (also known as the bombesin BB2 receptor), the NMB receptor (also known as the BB1 receptor) and a third, orphan receptor whose ligand is unknown, designated the BRS-3 receptor or BB3 receptor. These known receptors cannot, however, explain all of bombesin=s CNS effects, particularly bombesin=s effects on body temperature and grooming. This suggests that other bombesin receptor subtypes remain to be characterized. Our laboratory has now characterized two new recep tors related to the bombesin receptors. These receptors are very highly expressed in the CNS. These receptors have been designated GPCR-CNS1 and GPCR-CNS2. In the CNS, expression is primarily found in glia. Preliminary results suggest that each receptor is preferentially localized in different glial subtypes. Unlike the GRP receptor, these receptors are not present in fetal monkey lung. FUNDING SOURCE NIH NS35580 PUBLICATIONS Leng N, Gu GB, Simerly RB, Spindel ER. Molecular cloning and characterization of GPCR/CNS2, a novel G-protein coupled receptor which is highly expressed in the central nervous system. Soc Neurosci Abstr 24:1091, 1998 (abstract 432.11).

铃蟾肽样肽包含一个大的肽家族 最初是两栖动物的特征，后来发现广泛存在 分布于哺乳动物。 CNS 对大鼠施用铃蟾肽 对食欲、体温、仪容仪表、心率、 和胃肠功能。 两种哺乳动物铃蟾肽样肽， 胃泌素释放肽 (GRP) 和神经调节素 B (NMB) 迄今为止的特征。 目前，三种哺乳动物的铃蟾肽样 肽受体已被表征； GRP 受体（也 称为铃蟾肽 BB2 受体）、NMB 受体（也称为 BB1 受体）和第三个孤儿受体，其配体是 未知，指定为 BRS-3 受体或 BB3 受体。 这些已知的 然而，受体不能解释所有铃蟾肽的中枢神经系统作用， 尤其是铃蟾肽对体温和梳理行为的影响。 这表明其他铃蟾肽受体亚型仍有待研究。 特点。 我们的实验室现在已经确定了两种新的接收方法 与铃蟾肽受体相关的受体。 这些受体非常 在中枢神经系统中高表达。 这些受体已被指定 GPCR-CNS1 和 GPCR-CNS2。 在 CNS 中，表达主要存在于 神经胶质细胞。 初步结果表明每个受体 优先定位于不同的神经胶质亚型。 与 GRP 不同 受体，这些受体不存在于胎猴肺中。 资金来源 NIH NS35580 出版物 Leng N, Gu GB, Simerly RB, 斯宾德尔 ER。 GPCR/CNS2 的分子克隆和表征 新型 G 蛋白偶联受体，在 中枢神经系统。 Soc Neurosci Abstr 24:1091, 1998（摘要 432.11）。