Childbearing and post-partum ovarian cancer risk

生育和产后卵巢癌风险

• 批准号: 6462856
• 负责人: CHUNG-CHENG HSIEH
• 金额: $ 16.77万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6462856
• 关键词: Scandinavian; Scandinavian country; age at pregnancy; age difference; cancer risk; clinical research; disease /disorder etiology; dizygotic twins; female; hormone related neoplasm /cancer; human data; information systems; monozygotic twins; neoplasm /cancer epidemiology; ovary neoplasms; parity; pathologic process; patient /disease registry; progesterone

The aims of the present study are to further examine the complex associations between childbearing and ovarian cancer risk. We will evaluate the hypothesis that pregnancy-dependent clearance effect reduces ovarian cancer risk by examining whether the protective effect of childbearing diminishes over time. We will examine indirectly whether exposure to progesterone contributes to the protective effect of childbearing by evaluating the effect of twinning (dizygotic twins in particular) and birth spacing. We will utilize a linked database from Swedish nation-wide registries (the Fertility Register, the Cancer Register, and the Twin Register). Members of the study cohort are all women who were born from 1925 and on and listed in the Fertility Register. We adopt a nested case-control sampling design to allow more efficient analyses. Case subjects are more than 9,000 cohort members diagnosed with invasive ovarian cancer tumors from 1961 to 1999 as identified by the Cancer Register. Control subjects are approximately 45,000 women randomly selected from the Fertility Register and matched by birth year with the index cases. We will model the data through conditional logistic regression to estimate odds ratios associated with reproductive study characteristics. Further analyses will examine the effect of age at last birth in different age groups and assess postpartum time-dependent ovarian cancer risk. This study seeks to further our understanding of the mechanisms behind the protective effect of childbearing utilizing the uniquely large database, the ability to determine the zygosity of twins, the analyses within specific age groups of women, and the known endocrine physiology associated with the study variables. Examination of the effect of delayed childbearing in younger women could provide further insight into the potential mechanism attributable to its putative protective effect against ovarian cancer occurrence, while examination of the effect of childbearing in older women can better document whether the pregnancy-dependent clearance effect diminishes with time. Improved understanding of the etiology and carcinogenic process of ovarian cancer could lead to the development of hormonal prevention methods that mimic relevant aspects of the protective effect of childbearing.

本研究的目的是进一步研究生育和卵巢癌风险之间的复杂关联。 我们将评估以下假设，即通过检查育种的保护作用是否随着时间的流逝而减少，依赖妊娠依赖性清除效应会降低卵巢癌的风险。 我们将通过评估双胞胎（尤其是双叶双胞胎）和出生间距来间接检查孕酮的暴露是否有助于育生物的保护作用。 我们将利用来自瑞典全国登记处的链接数据库（生育登记册，癌症登记册和双胞胎登记册）。 研究队列的成员都是从1925年出生并在生育登记册中列出并列出的妇女。 我们采用嵌套的病例对照采样设计，以进行更有效的分析。 案例受试者是癌症登记发现的1961年至1999年诊断为侵入性卵巢癌肿瘤的9,000多名队列成员。控制受试者大约是从生育登记册中随机选择的45,000名妇女，并按照出生年份与指数案件相匹配。 我们将通过条件逻辑回归对数据进行建模，以估计与生殖研究特征相关的几率比率。 进一步的分析将检查不同年龄段的最后出生年龄的影响，并评估产后依赖性的卵巢癌风险。 这项研究旨在进一步理解我们利用独特的大数据库，确定双胞胎的糊状，特定女性年龄段的分析以及与研究变量相关的已知内分泌生理学的分析的能力，确定双胞胎的糊状，确定双胞胎的合影的能力。检查年轻妇女延迟生育的影响可以进一步了解归因于其针对卵巢癌发生的推定保护作用的潜在机制，而对育龄在老年妇女的影响的检查可以更好地记录是否依赖于妊娠依赖性清除效应是否会随着时间的推移而减少。对卵巢癌的病因和致癌过程的了解得以提高，可能导致荷尔蒙预防方法的发展，这些方法模仿了生育的保护作用的相关方面。