Intrapartum complications and neurologic morbidity

产时并发症和神经系统发病率

• 批准号: 7107553
• 负责人: Vera Ehrenstein
• 金额: $ 0.28万
• 依托单位: AARHUS UNIVERSITY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107553
• 关键词: Scandinavian country; age at pregnancy; biomarker; birth; clinical research; cognition; disease /disorder proneness /risk; epilepsy; gestational age; human birth weight; human data; human morbidity; labor complications; longitudinal human study; nervous system disorder epidemiology; predoctoral investigator; sensory discrimination; smoking

DESCRIPTION (provided by applicant): Two studies of neurologic sequellae of perinatal complications are proposed. Using data from Danish population registers, the first study examines the association between post-term (>42 weeks) delivery and risk of epilepsy in childhood. Birth data on over 300,000 singletons born in Denmark in 1980-2001 are available. Risks epilepsy in the first 12 years of life are estimated for the entire post-term delivery group, and for each week of prolonged gestation. These are then compared with the epilepsy risk among term babies (38-42 weeks). Risk ratios are examined in the groups according to birth weight, mode of delivery, birth presentation, maternal age at delivery, and smoking. Cox's regression will be used to obtain adjusted risk ratio estimates while accounting for differential follow-up. The second study focuses on suboptimal (<7) 5- minute Apgar score as a clinical predictor of lowered cognitive function and sensory acuity. Birth registry data from Danish draftees born in 1978-1983 are linked to the results of standardized intelligence, hearing, and vision tests from the Draft board. Tests' results are compared for those with suboptimal vs. normal Apgar score. The association is further examined according to other perinatal variables as in the first study.

描述（由申请人提供）：提出了两项​​对围产期并发症的神经系统后遗症的研究。使用丹麦人群登记册的数据，第一项研究检查了童年后术后（> 42周）的分娩（> 42周）之间的关联。 1980 - 2001年有超过300,000个单身人士的出生数据。估计整个期限后分娩组的风险癫痫，以及妊娠期延长的风险。然后将这些与年龄婴儿之间的癫痫风险进行比较（38-42周）。根据出生体重，分娩方式，出生陈述，分娩时的产妇年龄和吸烟在组中检查风险比率。在考虑差异随访的同时，COX的回归将用于获得调整后的风险比率估计。第二项研究的重点是次优（<7）5分钟APGAR评分，作为降低认知功能和感觉敏锐度的临床预测指标。 1978 - 1983年出生的丹麦草稿的出生注册表数据与标准化情报，听力和视力测试的结果有关。比较次优与正常APGAR评分的测试结果。与第一项研究一样，根据其他围产期变量进一步检查了该关联。