Hormone markers during pregnancy and ovarian concer risk

怀孕期间的激素标记物和卵巢癌风险

• 批准号: 6916574
• 负责人: SVEN H CNATTINGIUS
• 金额: $ 5.4万
• 依托单位: KAROLINSKA INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6916574
• 关键词: Scandinavian country; age at pregnancy; biomarker; cancer risk; clinical research; disease /disorder etiology; hormone related neoplasm /cancer; human data; medical records; neoplasm /cancer epidemiology; ovary neoplasms; placenta; placental hormones; pregnancy; pregnancy disorder; pregnancy toxemia /hypertension; statistics /biometry

DESCRIPTION (provided by applicant): Background: Ovarian carcinogenesis is probably in large part due to factors associated with reproduction. During pregnancy, large amounts of estrogens and progesterones are produced by the placenta. The levels of pregnancy hormones are influenced by pregnancy characteristics, such as gestational age. Despite the evidence that risk of ovarian cancer is reduced with increasing parity, while incomplete pregnancies, such as spontaneous abortions, appear not to influence risk, studies of associations between indicators of hormonal exposures during pregnancy and subsequent risks of ovarian cancer are lacking. Specific aims: 1. To study risk of ovarian cancer by markers of hormone exposures during pregnancy, including birthweight, gestational age, single or multiple birth, pregnancy-induced hypertensive diseases, and placental weight; 2. to study if the protective effects of increasing parity and a high age at first birth are influenced by markers of hormone exposures during pregnancy; and 3. to assess the importance of other factors on ovarian cancer risk. Methods: We will establish a cohort of more than 1.2 million women who delivered their first infant between 1973 and 2000, and were included in the nation-wide Swedish Medical Birth Register. We plan to retrieve information about maternal characteristics, pregnancy complications, placental weight, birth characteristics for all births to these women, and women will be followed up in population-based registers with regards to gynecological surgery, vital status, and ovarian cancer. We estimate to include at least 1,000 women with ovarian cancer. We will use Cox proportional hazards models and Poisson regression models to estimate ovarian cancer incidence rate ratios for exposures of interest. Significance: Little new knowledge of the etiology of ovarian cancer has been gained during recent decades. The Swedish research registers will allow us to perform a large cost-effective cohort study where information on markers of hormone exposure during pregnancy has been collected prospectively.

描述（由申请人提供）： 背景：卵巢癌发生可能很大程度上是由于与繁殖有关的因素。在怀孕期间，胎盘会产生大量的雌激素和孕激素。怀孕激素的水平受妊娠特征（例如胎龄）的影响。尽管有证据表明，卵巢癌的风险随着平等性的增加而降低，而怀孕（例如自发流产）似乎不影响风险，但缺乏对妊娠期激素暴露指标与随后发生卵巢癌风险的关联的研究。 具体目的：1。通过怀孕期间的激素暴露的标记来研究卵巢癌的风险，包括出生体重，胎龄，单身或多重出生，怀孕引起的高血压疾病和胎盘体重； 2。研究是否在怀孕期间受激素暴露的标记影响了平等和高龄的保护作用是否受到激素暴露的影响； 3。评估其他因素对卵巢癌风险的重要性。 方法：我们将在1973年至2000年之间建立超过120万妇女的队列，这些妇女在1973年至2000年间分娩，并被包括在瑞典瑞典医学出生登记册中。我们计划检索有关孕产妇特征，妊娠并发症，胎盘体重，所有分娩的出生特征的信息，并且将在基于人群的登记记录中跟踪有关妇科手术，重要状态和卵巢癌的妇女。我们估计至少包括1,000名卵巢癌女性。我们将使用COX比例危害模型和泊松回归模型来估计感兴趣的暴露率卵巢癌发病率比率。 意义：近几十年来，几乎没有对卵巢癌病因的新知识。瑞典的研究登记册将使我们能够进行大量的成本效益的队列研究，其中已经收集了有关怀孕期间激素暴露标记的信息。