INTRACELLULAR ROLE OF CLATHRIN AND ITS REGULATION

网格蛋白的细胞内作用及其调控

• 批准号: 6342863
• 负责人: THERESA Joyce O'HALLORAN
• 金额: $ 26.68万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342863
• 关键词: Dictyostelium; Drosophilidae; cell cycle; clathrin; cytoplasm; endocytosis; gene targeting; genetically modified animals; intracellular transport; molecular cloning; mutant; myosins; phenotype; protein purification; protein structure function; protein transport; tissue /cell culture

DESCRIPTION: In the first grant period a deletion of the clathrin heavy chain was constructed. The investigator proposes to take advantage of the clathrin null cells to explore the structural details of clathrin assembly. A variety of truncations will be introduced into the nulls cells and the assembled clathrin analyzed for structural and functional changes.

描述：在第一个授权期内，网格蛋白重链的删除 链已构建。 研究者建议利用 网格蛋白无效细胞探索网格蛋白组装的结构细节。 各种截断将被引入到空单元格中，并且 分析组装的网格蛋白的结构和功能变化。