EXPOSURE TO RADON AND CANCER RISK

接触氡气和癌症风险

• 批准号: 6432308
• 负责人: Dale P Sandler
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432308
• 关键词: cancer registry /resource; cancer risk; child (0-11); clinical research; environment related neoplasm /cancer; environmental toxicology; human subject; leukemia; longitudinal human study; lung neoplasms; minings; neoplasm /cancer epidemiology; occupational hazard; pediatric neoplasm /cancer; radiation carcinogen; radon; statistics /biometry; toxicant interaction; uranium

Aims:1) To assess the role of lifetime residential exposure to radon and risk of lung cancer while taking into account active and passive exposure to cigarette smoke. 2) To contribute to national estimates of risk associated with radon exposure by pooling data with other studies of residential radon exposure and contrasting observed risk estimates with those predicted based on studies of uranium miners. 2) To explore other risk factors for lung cancer, including environmental exposures ascertained through linkage with geographically based data systems. Factors of interest include particulate matter air pollution, arsenic in drinking water, altitude, and numerous occupational, medical, and lifestyle factors ascertained from personal interviews. 3) To explore the risk for childhood cancers associated with residential radon exposure. Accomplishments: Data analysis has now been completed to assess lung cancer and childhood leukemia risk associated with residential radon exposure. For the lung cancer study, a uniform data structure has been created, allowing us to link a complex, multi-level data set. Residence addresses have been geocoded to facilitate linkage with geographical databases on factors associated with radon levels in homes. Housing characteristics associated with radon levels have also been identified and methods for dealing with missing exposure data have been evaluated. Although radon levels are lower than predicted, our coverage of the exposure time-window of interest is quite good. 20% of study subjects have complete coverage of the years between age 25 and 5-years before diagnosis. 60% have complete data for the years between 25 and 5 years prior to diagnosis or interview. Results suggest little overall lung cancer risk from radon at the low doses studied, but the data are consistent with estimates based on extrapolating from known effects in miners. Data on particulate matter air pollution have been obtained and a mapping strategy has been devised to estimate exposures for all houses in the study sample. Maps have been completed and analysis has begun to evaluate the link between this exposure and lung cancer risk. A similar approach will be used to link residences to information on arsenic in drinking water. Additional analyses will focus on high risk subtypes and other lung cancer risk factors such as environmental tobacco smoke exposure, occupational factors, altitude, and prior lung disease.

目的：1）评估终生住宅暴露于ra的作用和肺癌的风险，同时考虑了积极和被动暴露于香烟烟雾的情况下。 2）通过与其他关于住宅ra暴露的研究合并数据以及基于对铀矿工研究预测的风险估计的其他研究来促进与ra暴露相关的风险估计。 2）探索肺癌的其他危险因素，包括通过与基于地理的数据系统联系确定的环境暴露。 感兴趣的因素包括颗粒物空气污染，饮用水中的砷以及从个人访谈中确定的许多职业，医疗和生活方式因素。 3）探索与住宅ra暴露相关的儿童癌症的风险。成就：数据分析现已完成，以评估与住宅ra暴露有关的肺癌和儿童白血病风险。 对于肺癌研究，已经建立了统一的数据结构，使我们能够将复杂的多层次数据集链接起来。已经对居住地址进行了地理编码，以促进与与房屋中ra相关的因素的地理数据库联系。还已经确定了与ra含量相关的外壳特征，并评估了处理缺失的暴露数据的方法。 尽管ra的水平低于预期的水平，但我们对感兴趣的暴露时间窗口的覆盖范围相当不错。诊断前25至5岁之间的年龄在25至5岁之间的年度中，有20％的研究受试者的覆盖范围。 在诊断或访谈之前的25至5年之间，有60％的人拥有完整的数据。结果表明，在研究的低剂量下，rad的总体肺癌风险很小，但数据与基于矿工中已知效应的推断的估计是一致的。 已经获得了有关空气污染的数据，并设计了制图策略来估计研究样本中所有房屋的暴露。 图已经完成，分析开始评估这种暴露与肺癌风险之间的联系。 将使用类似的方法将住宅与饮用水中砷的信息联系起来。 其他分析将集中于高风险亚型和其他肺癌危险因素，例如环境烟草烟雾，职业因素，高度和先前的肺部疾病。