Genetics of Inflammatory Bowel Disease

炎症性肠病的遗传学

• 批准号: 6433684
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6433684
• 关键词: family genetics; genetic markers; genotype; human data; inflammatory bowel diseases; linkage mapping; molecular biology information system

This project to study the genetics of Inflammatory Bowel Disease(IBD) was initiated in this fiscal year in collaboration withDrs. Steven Brant and Theodore Bayliss of Johns HopkinsUniversity School of Medicine and with the International IBDConsortium. An international consortium of investigators who havepreviously published genome wide linkage screens for IBD wasformed and all members agreed to genotype the same markers in twocandidate regions on at least 50 highly families with bothparents and two or more affected children available forgenotyping. These data were then deposited into a common databaseat the University of Canberra, anonymized and then distributed tothe participating groups. Each group performed its own analysesof these data and presented them at a workshop in Australia inSeptember. Additional genotyping is ongoing and a manuscript isin preparation. Dr. Bailey-Wilson has been named head of theAnalysis committee for this consortium and will continue tointeract with Drs. Brant, Bayliss and the IBD Consortium onfuture analyses of the genetics of IBD. - Inflammatory bowel disease, Crohn's disease, ulcerative colitis, genetics, IBD Consortium - Human Subjects

这个研究炎症性肠病（IBD）遗传学的项目于本财年与 Drs. 合作启动。约翰·霍普金斯大学医学院的 Steven Brant 和 Theodore Bayliss 以及国际 IBD 联盟。一个由先前发表过 IBD 全基因组连锁筛选的国际研究人员组成的联盟成立，所有成员都同意在至少 50 个父母双方都有且有两个或更多受影响儿童的高度家庭的两个候选区域中对相同的标记进行基因分型。然后，这些数据被存入堪培拉大学的一个公共数据库，经过匿名处理后分发给参与小组。每个小组都对这些数据进行了自己的分析，并在 9 月份在澳大利亚举行的研讨会上展示了它们。额外的基因分型正在进行中，手稿正在准备中。 Bailey-Wilson 博士已被任命为该联盟分析委员会的负责人，并将继续与 Drs 进行互动。 Brant、Bayliss 和 IBD 联盟对 IBD 遗传学的未来分析。 - 炎症性肠病、克罗恩病、溃疡性结肠炎、遗传学、IBD 联盟 - 人类受试者