Asian Cohort for Alzheimer's Disease (ACAD)

亚洲阿尔茨海默病队列 (ACAD)

基本信息

批准号：
10555689
负责人：
HELENA Chang CHUI
金额：
$ 832.6万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555689
关键词：
Address Advocacy Affect Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Area Asia Asian Asian Americans Asian population Awareness Biological Markers Biology Blood Blood specimen Canada Caregivers Categories Chinese Clinical Clinical Data Clinical Research Cognitive Collaborations Collection Communities Community Health Community Outreach Consensus DNA Data Data Collection Data Set Dementia Diagnosis Diagnostic Diet Disease Drug Targeting Etiology European ancestry Family Frequencies Funding Future Genetic Genetic Diseases Genetic Research Genetic study Genotype Gold Health Personnel Health care facility Hour Human Genetics Immigration Infrastructure International Investments Knowledge Koreans Language Leadership Life Experience Life Style Literature Long-Term Care Meta-Analysis Minority Groups Modeling Molecular Neurologic Neurology Participant Pathway interactions Patients Persons Physical activity Plasma Population Population Heterogeneity Procedures Protocols documentation Recording of previous events Research Research Project Grants Resources Risk Risk Factors SNP array Sampling Scientist Socioeconomic Status Staging Training Translating Translation Process United States Variant Vietnamese adjudication aged clinical predictors cohort community engagement data management data sharing effective therapy experience follow-up gene discovery genetic variant genome sequencing genome wide association study genome-wide geriatric depression health disparity improved insight metropolitan multi-ethnic new therapeutic target non-genetic outreach polygenic risk score precision medicine clinical trials prevent quality assurance recruit reference genome repository retention rate risk variant saliva sample screening sex synergism whole genome

项目摘要

Overall Abstract Alzheimer’s disease (AD) affects 5.8 million people in the United States and is an immense burden on our economy, patients and caregivers. Genome-wide association studies (GWAS) have successfully led to 25 genome-wide significant loci associated with AD risk and many more associations with key clinical covariates. Most of these findings are made on participants with European ancestry, although efforts to study other minority populations are taking off. Knowledge about AD genetics among Asian Americans is especially limited due to lack of participants. Comprising 6% of the US populace, Asian Americans are under-sampled and deserve more scientific investment. We propose the Asian Cohort for Alzheimer’s Disease (ACAD), the first large Alzheimer’s Disease (AD) genetics cohort for Asians in United States (US) and Canada. To address recruitment barriers, we assembled a team of scientists, clinicians, and community partners with collaborative history and expertise in AD research, human genetics, and Asian community outreach. We propose to recruit 5,081 participants aged 60 years or older and of Chinese, Korean, and Vietnamese ancestry from metropolitan areas across US and Canada in collaboration with community health providers or long-term care facilities that serve Asian communities. We will collect DNA and plasma biomarkers and use validated, translated data collection forms and clinical/diagnostic protocols. To support these recruitment and data collection activities, we will form six Cores that provide administrative oversite, outreach, clinical expertise, data management, biosample management, and training and quality assurance to support recruitment and analysis activities. All samples will be genotyped using SNP arrays and imputed using a large Asian-specific reference panel of whole genome sequencing data from international Asian cohorts. We propose two Research Projects that will analyze genetic, biomarker and clinical data to investigate impact of lifestyle risk factors, genetic variants for AD risk, evaluate differential effects of sex and APOE genotypes on AD risk, and predict clinical diagnosis of AD using genetic and lifestyle risk scores. We will replicate these findings through meta-analysis collaborations with international Asian cohorts and AD studies from other populations.

总体抽象阿尔茨海默氏病（AD）在美国影响了580万人，这是我们的巨大伯宁经济，患者和照料者。全基因组关联研究（GWAS）已成功导致25 全基因组的重要局部与AD风险相关，以及与关键临床协变量的更多关联。这些发现中的大多数都是针对欧洲血统的参与者提出的，尽管努力研究其他少数族裔正在起飞。在亚裔美国人中有关AD遗传学的知识特别有限由于缺乏参与者。亚裔美国人占美国平民的6％，而不是值得获得更多的科学投资。我们提出了亚洲阿尔茨海默氏病（ACAD）的亚洲队列，这是第一个大型阿尔茨海默氏病（AD）美国和加拿大亚洲人的遗传学队列。为了解决招聘障碍，我们集会了一个科学家，临床医生和社区合作伙伴的团队，具有合作历史和广告研究专业知识的团队，人类遗传学和亚洲社区宣传。我们建议招募5,081名60岁或来自美国和加拿大的大都市地区的中国人，韩国和越南血统与为亚洲社区服务的社区卫生提供者或长期护理机构的合作。我们将收集DNA和等离子体生物标志物，并使用经过验证的，翻译的数据收集表和临床/诊断方案。为了支持这些招聘和数据收集活动，我们将组成六个核心提供行政上场，外展，临床专业知识，数据管理，生物样本管理，以及培训和质量保证，以支持招聘和分析活动。所有样本将是使用SNP阵列进行了基因分型，并使用整个基因组的大亚洲特异性参考面板进行估算从国际亚洲队列中进行测序数据。我们提出了两个研究项目，这些项目将分析遗传，生物标志物和临床数据研究生活方式风险因素的影响，AD风险的遗传变异，评估性别和APOE基因型对AD风险的差异影响，并使用遗传来预测AD的临床诊断和生活方式风险分数。我们将通过荟萃分析合作复制这些发现来自其他人群的国际亚洲人群和广告研究。