Alzheimer Disease Research Center

阿尔茨海默病研究中心

基本信息

批准号：
10641135
负责人：
HELENA Chang CHUI
金额：
$ 6.93万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641135
关键词：
Address Advisory Committees Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease therapeutic Alzheimer’s disease biomarker Amyloid Amyloid beta-Protein Asian Basic Science Biological Biological Markers Biological Sciences Blood Blood - brain barrier anatomy Blood Vessels Brain California Caregivers Catchment Area Cells Cerebrovascular system Clinical Clinical Research Clinical Trials Cohort Studies Coupled DNA Data Set Databases Development Devices Diagnosis Disease Doctor of Philosophy Enrollment Evaluation Faculty Finches Fostering Goals Health Sciences Home Image Informatics Institutes International Investments Latino Latino Population Latinx Latinx population Leadership Los Angeles Magnetic Resonance Imaging Medical Genetics Mentors Metabolic Methods Minority Minority Groups Neurosciences Participant Pathogenesis Pathologic Pharmaceutical Preparations Phase Phase I/II Clinical Trial Physiology Plasma Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Principal Investigator Recording of previous events Research Research Design Research Institute Research Personnel Resources Risk Factors Role Scientist Standardization Stroke Structure System Tissues Training Translational Research Underrepresented Minority Underrepresented Populations Universities Vascular Dementia Vascular Diseases Work big data management brain research career cohort data management doctoral student education research experience imaging informatics member neurogenetics neuroimaging neuropathology neurovascular unit novel therapeutics outreach programs recruit research study specific biomarkers standard measure tau Proteins treatment center vascular contributions

项目摘要

Abstract The 3 overarching goals of the USC Alzheimer Disease Research Center (ADRC) are to: 1) Elucidate vascular contributions to Alzheimer disease (AD), 2) catalyze basic, clinical, and translational research in AD at USC, and 3) contribute expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The ADRC is led by 3 multiple PD/PIs: Chui, Zlokovic, and Toga and comprised of 6 required cores, the required Research Education Component (REC), and 1 optional imaging core. The Administration Core (Chui, Zlokovic, Toga) provides administrative and scientific oversight across USC ADRC, including fostering development projects and supporting ADRC-affiliated studies. The Clinical Core (Schneider, Ringman, Chui) performs standardized evaluations and diagnoses using the NACC Uniform Data Set (UDS), enrolls and follows participants in our 2 primary ADRC cohorts: Vascular Cohort Study (VCS) and Brain Research Study (BRS). The Data Management and Statistical Core (Toga and Chen) oversees the NACC UDS database, provides study- and core-specific databases and curates our large imaging data sets as a local and national resource. The Neuropathology Core (Miller and Hawes) performs standardized neuropathological examinations, stores and distributes biological tissues to research investigators. The Outreach, Recruitment, and Engagement Core (Aranda) works closely with the Clinical Core to recruit and retain the primary ADRC cohort, focusing on under- represented minority groups (especially Latinx), and the development of a participant-caregiver dyad resource database. The Biomarker Core (Zlokovic) uses state of the art methods to determine cell-and system-specific biomarkers related to the neurovascular unit, as well as to measure standard AD biomarkers. The Imaging Core (Toga and Pa) provides high field (3T and 7T) MR imaging, as well as amyloid/tau PET scans. The Research Education Component (Yassine) is dedicated to mentoring post-doctoral students committed to the study of minority issues in Alzheimer disease and related disorders. The USC Health Science Campus is located near high Latinx catchment areas. Treatable vascular-metabolic risk factors (VMRF) are particularly prevalent among the Latinx population and dovetail with the research focus of the USC ADRC.

抽象的南加州大学阿尔茨海默氏病研究中心（ADRC）的三个总体目标是：1）阐明血管对阿尔茨海默氏病（AD）的贡献，2）催化AD的基本，临床和翻译研究 USC和3）在血管疾病，生物标志物和成像方面贡献专业知识倡议。 ADRC由3个多个PD/PIS领导：Chui，Zlokovic和Toga，由6个必需的核心组成，所需的研究教育部分（REC）和1个可选成像核心。管理核心（Chui，Zlokovic，toga）在USC ADRC上提供行政和科学监督，包括促进开发项目和支持ADRC相关研究。临床核心（Schneider，Ringman，Chui）使用NACC统一数据集（UDS）执行标准化的评估和诊断，注册和关注我们2个主要ADRC队列的参与者：血管队列研究（VCS）和脑研究（BRS）。数据管理和统计核心（Toga和Chen）负责监督NACC UDS数据库研究和核心特异性数据库并策划了我们的大型成像数据集作为本地和国家资源。神经病理学核心（Miller和Hawes）进行标准化的神经病理检查，商店并将生物组织分配给研究人员。外展，招聘和参与核心（Aranda）与临床核心紧密合作以招募并保留主要ADRC队列，重点是代表少数群体（尤其是拉丁裔），以及参与者的二元组资源的发展数据库。生物标志物核心（Zlokovic）使用最新方法来确定细胞和系统特异性与神经血管单元以及测量标准AD生物标志物有关的生物标志物。成像核心（Toga和PA）提供高场（3T和7T）MR成像，以及淀粉样蛋白/TAU PET扫描。研究教育部分（Yassine）致力于指导致力于研究的博士后学生阿尔茨海默氏病和相关疾病中的少数群体问题。 USC健康科学校园位于高拉丁裔集水区。可治疗的血管代谢危险因素（VMRF）尤为普遍 Latinx人群和与USC ADRC的研究重点相吻合。